This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Transcriptional activator protein Pur-beta.
Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine- rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter.
Human | |
---|---|
Gene Name: | PURB |
Uniprot: | Q96QR8 |
Entrez: | 5814 |
Belongs to: |
---|
PUR DNA-binding protein family |
MGC126784; PURBETA; purine-rich element binding protein B
Mass (kDA):
33.241 kDA
Human | |
---|---|
Location: | 7p13 |
Sequence: | 7; NC_000007.14 (44876299..44885530, complement) |
Expressed in myocardium of heart failure patients.
Nucleus.
PMID: 1448097 by Bergemann A.D., et al. Sequence of cDNA comprising the human pur gene and sequence-specific single-stranded-DNA-binding properties of the encoded protein.
PMID: 11417483 by Lezon-Geyda K., et al. Deletions of PURA, at 5q31, and PURB, at 7p13, in myelodysplastic syndrome and progression to acute myelogenous leukemia.