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Pumilio homolog 2 Antibodies
AND PUM2 ELISA kits, Pumilio homolog 2 Proteins
Many biological assays use antibodies to detect Pumilio homolog 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Pumilio homolog 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Pumilio homolog 2 antibodies...
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PUM2 Infographic by Boster Bio
All PUM2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IP, IF, ICC, WB
$370
Cat # M03347
100 μl/vial
Cat # M03347
100 μl/vial
PUM2 Overview
Facts about Pumilio homolog 2.
Pumilio homolog 2 (PUM2)
Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187).
Mediates post- transcriptional repression of transcripts via different mechanisms: functions via direct recruiting of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and easing miRNA regulation (PubMed:22345517).
Gene Information
| Human | |
|---|---|
| Gene Name: | PUM2 |
| Uniprot: | Q8TB72 |
| Entrez: | 23369 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
FLJ36528; KIAA0235PUMH2PUML2; MGC138251; MGC138253; PUM2; PUMH2; pumilio (Drosphila) homolog 2; pumilio homolog 2 (Drosophila); pumilio homolog 2; Pumilio-2; PUML2
Molecular Weight
Mass (kDA):
114.216 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p24.1 |
| Sequence: | 2; NC_000002.12 (20248691..20352253, complement) |
Tissue Specificity
Expressed in male germ cells of adult testis (at protein level). Highly expressed in testis and ovary. Predominantly expressed in stem cells and germ cells. Expressed at lower level in brain, heart, kidney, liver, muscle, placenta, intestine and stomach Expressed in cerebellum, corpus callosum, caudate nucleus, hippocampus, medulla oblongata and putamen. Expressed in all fetal tissues tested.
Subcellular Localizations
Cytoplasm. Cytoplasmic granule. Cytoplasm, perinuclear region. The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules. Colocalizes with NANOS1 and SNAPIN in the perinuclear region of germ cells.
Diseases
- Neoplasms
- Azoospermia
- Kyphosis Deformity Of Spine
- Infertility
- Sterility
- Nervousness
- Trematode Infections
- Male Infertility
- Tumor Progression
- Hypoxia
- Essential Tremor
- Brain Neoplasms
Interacting Proteins
- DAZ1
Pathways
- Translation
- Cell Development
- Germ Cell Development
- Stem Cell Maintenance
- Cell Division
- Cell Differentiation
- Oocyte Maturation
- Localization
- Rna Interference
- Transport
- Asymmetric Cell Division
- Cell Cycle
- Meiosis
PTMs
- Phosphorylation
Research Areas
- Stem Cell Markers
- Translation Control
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PUM2
bosterbio.com/bosterbio-gene-info-cards/PUM2
References
PMID: 12459267 by Spassov D.S., et al. Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins.
PMID: 12511597 by Moore F.L., et al. Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins.