ARHGEF18 Antibodies

AND ARHGEF18 ELISA kits, ARHGEF18 Proteins

Many biological assays use antibodies to detect ARHGEF18, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ARHGEF18 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ARHGEF18 antibodies...

We validate the specificity of these antibodies to ARHGEF18 by testing them on tissues known to express ARHGEF18 positively and negatively. Browse below to find the ARHGEF18 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ARHGEF18 Infographic by Boster Bio

All ARHGEF18 Products

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Anti-p114RhoGEF (ARHGEF18) Mouse Monoclonal Antibody [Clone ID: OTI6D10]

Human

IHC, WB

$523
Cat # M08684
100 µl

ARHGEF18 Overview

Facts about Rho guanine nucleotide exchange factor 18.

ARHGEF18 3D structure. Source: alphafold

Rho guanine nucleotide exchange factor 18 (ARHGEF18)

Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its stimulation induces formation of actin stress fibers.

Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Doesn't act as a GEF for CDC42.

Gene Information

Human
Gene Name:	ARHGEF18
Uniprot:	Q6ZSZ5
Entrez:	23370

Family

Belongs to:

No superfamily

Alternative Names

114 kDa Rho-specific guanine nucleotide exchange factor; EC 3.4.24; EC 3.6.1; KIAA0521rho guanine nucleotide exchange factor 18; MGC15913; p114RhoGEF; P114-RhoGEF; P114-RHO-GEF; Rho/Rac guanine nucleotide exchange factor (GEF) 18; Rho/Rac guanine nucleotide exchange factor 18; Rho-specific guanine nucleotide exchange factor p114; SA-RhoGEF; Septin-associated RhoGEF

Molecular Weight

Mass (kDA):
151.642 kDA

Genomic Context


Human

Location:	19p13.2
Sequence:	19; NC_000019.10 (7348901..7476990)

Tissue Specificity

Expressed in all tissues tested with highest expression in kidney and pancreas. Weakly or not expressed in liver, skeletal muscle and testis.

Subcellular Localizations

Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane. Apical cell membrane. In unactivated eosinophils, distributed around the cell periphery in the perimembranous region (PubMed:29601110). In activated eosinophils, relocates to the tip of the nucleopod, a membrane structure formed during activation when the nucleus moves to one end of the cell, and is also concentrated in membrane protrusions at the opposite end of the cell (PubMed:29601110). Localizes to the apical cell membrane in epithelial cells (PubMed:22006950).