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Pumilio homolog 1 Antibodies
AND PUM1 ELISA kits, Pumilio homolog 1 Proteins
Many biological assays use antibodies to detect Pumilio homolog 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Pumilio homolog 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Pumilio homolog 1 antibodies...
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PUM1 Infographic by Boster Bio
All PUM1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
Flow Cytometry, IP, IF, IHC, ICC, WB
$405
Cat # A02111-1
100ul
Cat # A02111-1
100ul
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M02111-1
100 μl/vial
Cat # M02111-1
100 μl/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A02111-2
100 μg/vial
Cat # A02111-2
100 μg/vial
PUM1 Overview
Facts about Pumilio homolog 1.
Pumilio homolog 1 (PUM1)
Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is linked to the Nanos Response Element (NRE) (PubMed:21572425, PubMed:18328718, PubMed:21653694, PubMed:21397187).
Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:20818387, PubMed:20860814, PubMed:22345517).
Gene Information
| Human | |
|---|---|
| Gene Name: | PUM1 |
| Uniprot: | Q14671 |
| Entrez: | 9698 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
HSPUM; KIAA0099PUML1; PUM1; PUMH; PUMH1; PUMH1pumilio homolog 1; pumilio (Drosophila) homolog 1; pumilio homolog 1 (Drosophila); Pumilio-1; PUML1
Molecular Weight
Mass (kDA):
126.473 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p35.2 |
| Sequence: | 1; NC_000001.11 (30931506..31065717, complement) |
Tissue Specificity
Expressed in brain, heart, kidney, muscle, intestine and stomach. Not expressed in cerebellum, corpus callosum, caudate nucleus, hippocampus, medulla oblongata and putamen. Expressed in all fetal tissues tested.
Subcellular Localizations
Cytoplasm. Cytoplasm, P-body. Cytoplasmic granule. Recruited to cytoplasmic stress granules upon viral infection.
Diseases
- Malignant Neoplasms
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Neoplasms
- Malignant Paraganglionic Neoplasm
- Kyphosis Deformity Of Spine
- Invasive Breast Carcinoma
- Carcinoma
- Cholangiocarcinoma
- Endometrial Polyp
- Brain Neoplasms
Pathways
- Translation
- Localization
- Cell Development
- Oocyte Maturation
- Cell Division
- Asymmetric Cell Division
- Germ Cell Development
- Rna Interference
- Cell Proliferation
- Gene Silencing
- Stem Cell Maintenance
- Neurogenesis
- Embryo Development
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PUM1
bosterbio.com/bosterbio-gene-info-cards/PUM1
References
PMID: 12459267 by Spassov D.S., et al. Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins.
PMID: 12771951 by Dazard J.-E., et al. Genome-wide comparison of human keratinocyte and squamous cell carcinoma responses to UVB irradiation: implications for skin and epithelial cancer.