PTPRZ1 Antibodies

AND PTPRZ1 ELISA kits, PTPRZ1 Proteins

Many biological assays use antibodies to detect PTPRZ1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PTPRZ1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PTPRZ1 antibodies...

We validate the specificity of these antibodies to PTPRZ1 by testing them on tissues known to express PTPRZ1 positively and negatively. Browse below to find the PTPRZ1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PTPRZ1 Infographic by Boster Bio

All PTPRZ1 Products

Product

Figures

Specificity

Applications

Price

Anti-PTP zeta PTPRZ1 Antibody

7 Q&As

Human, Mouse, Rat

$399
Cat # A03510
100μl

PTPRZ1 Overview

Facts about Receptor-type tyrosine-protein phosphatase zeta.

PTPRZ1 3D structure. Source: alphafold

Receptor-type tyrosine-protein phosphatase zeta (PTPRZ1)

Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells to mature, fully myelinating oligodendrocytes.

May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably through the dephosphorylation of proteins which are part of important signaling cascades (By similarity).

Gene Information

Human
Gene Name:	PTPRZ1
Uniprot:	P23471
Entrez:	5803

Family

Belongs to:

protein-tyrosine phosphatase family

Alternative Names

3F8 CSPG ; HPTPZ; phosphacan; protein tyrosine phosphatase, receptor-type, Z polypeptide 1; PTP beta/zeta; PTP18; PTPRZ; PTPRZ1; PTPZ; receptor-type, zeta polypeptide 1; RPTPB; RPTPbeta

Molecular Weight

Mass (kDA):
254.587 kDA

Genomic Context


Human

Location:	7q31.32
Sequence:	7; NC_000007.14 (121873161..122062036)

Tissue Specificity

Specifically expressed in the central nervous system, where it is localized in the Purkinje cell layer of the cerebellum, the dentate gyrus, and the subependymal layer of the anterior horn of the lateral ventricle. Developmentally regulated in the brain.

Subcellular Localizations

[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Secreted. A secreted form is apparently generated by shedding of the extracellular domain.; [Isoform 2]: Secreted.

Diseases

Nervousness
Tissue Adhesions
Neoplasms
Glioblastoma
Glioma
Malignant Neoplasms
Malignant Paraganglionic Neoplasm
Posttransfusion Purpura
Brain Neoplasms
Astrocytoma
Lymphoma
Neuroblastoma

Anaplastic Lymphoma
Brain Injuries
Cell Invasion
Spinal Cord Injuries
Epilepsy
Injury Of Central Nervous System

Interacting Proteins

ALK
CNTN1

Pathways

Cell Adhesion
Localization
Cell Migration
Regeneration
Pathogenesis
Myelination
Axon Guidance
Cell Proliferation
Glycosylation
Brain Development
Cell-cell Adhesion
System Development
Nervous System Development

Axon Regeneration
Cell Differentiation
Central Nervous System Development
Oncogenesis
Innervation
Reverse Transcription
Mrna Splicing

PTMs

Phosphorylation
Dephosphorylation

Glycosylation
Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PTPRZ1

References

PMID: 1323835 by Krueger N.X., et al. A human transmembrane protein-tyrosine-phosphatase, PTP zeta, is expressed in brain and has an N-terminal receptor domain homologous to carbonic anhydrases.

PMID: 8387522 by Levy J.B., et al. The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system.