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PTPRS Antibodies
AND PTPRS ELISA kits, PTPRS Proteins
Many biological assays use antibodies to detect PTPRS, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PTPRS in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PTPRS antibodies...
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PTPRS Overview
Facts about Receptor-type tyrosine-protein phosphatase S.
Receptor-type tyrosine-protein phosphatase S (PTPRS)
Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan (PubMed:21454754). Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth.
Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2.
Gene Information
| Human | |
|---|---|
| Gene Name: | PTPRS |
| Uniprot: | Q13332 |
| Entrez: | 5802 |
Family
| Belongs to: |
|---|
| protein-tyrosine phosphatase family |
Alternative Names
EC 3.1.3.48; protein tyrosine phosphatase PTPsigma; protein tyrosine phosphatase, receptor type, S; protein tyrosine phosphatase, receptor type, sigma; PTP sigma; PTPR sigma; PTPRS; PTPSIGMA; receptor-type tyrosine-protein phosphatase S; Receptor-type tyrosine-protein phosphatase sigma; R-PTP-S; R-PTP-sigma
Molecular Weight
Mass (kDA):
217.041 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.3 |
| Sequence: | 19; NC_000019.10 (5205503..5340812, complement) |
Tissue Specificity
Detected in peripheral blood plasmacytoid dendritic cells (at protein level) (PubMed:26231120). Detected in all tissues tested except for placenta and liver (PubMed:8524829, PubMed:8992885). Detected in peripheral blood plasmacytoid dendritic cells (PubMed:26231120).
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Perikaryon. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cell junction, synapse, synaptosome. Cell junction, synapse, postsynaptic density. Cell projection, neuron projection. Cell projection, growth cone. Is rapidly internalized when dendritic cells are stimulated with the TLR9 ligand cytidine-phosphate-guanosine (CpG) (PubMed:26231120). Detected in a punctate pattern along neurites and axon growth cones (By similarity).
Diseases
- Neoplasms
- Posttransfusion Purpura
- Pineal Gland Neoplasm
- Pineocytoma
- Malignant Neoplasms
- Papillary Neoplasm
- Nervousness
- Tissue Adhesions
- Papillary Tumor Of The Pineal Region
- Carcinoma
- Carcinoma, Papillary
- Malignant Squamous Cell Neoplasm
- Cell Transformation, Neoplastic
Interacting Proteins
- PTPRN
Pathways
- Cell Adhesion
- Regeneration
- Cell Proliferation
- Tissue Morphogenesis
- Programmed Cell Death
- Stem Cell Differentiation
- Cell Development
- Proteolysis
- Hypersensitivity
- Neurogenesis
- Localization
- Ureter Maturation
- Glucose Homeostasis
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PTPRS
bosterbio.com/bosterbio-gene-info-cards/PTPRS
References
PMID: 8524829 by Pulido R., et al. The LAR/PTP delta/PTP sigma subfamily of transmembrane protein- tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1.
PMID: 8992885 by Endo N., et al. Human protein tyrosine phosphatase-sigma: alternative splicing and inhibition by bisphosphonates.