PTPRR Antibodies

AND PTPRR ELISA kits, PTPRR Proteins

Many biological assays use antibodies to detect PTPRR, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PTPRR in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PTPRR antibodies...

We validate the specificity of these antibodies to PTPRR by testing them on tissues known to express PTPRR positively and negatively. Browse below to find the PTPRR antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PTPRR Infographic by Boster Bio

All PTPRR Products

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Product

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Specificity

Applications

Price

Anti-PTPRR Rabbit Monoclonal Antibody

Human, Mouse, Rat

IHC, WB

$370
Cat # M06905
100 μl/vial

PCPTP1 (PTPRR) (NM_002849) Human Over-expression Lysate

Human

$960
Cat # LS005801
100 µg

PTPRR Overview

Facts about Receptor-type tyrosine-protein phosphatase R.

PTPRR 3D structure. Source: alphafold

Receptor-type tyrosine-protein phosphatase R (PTPRR)

Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity).

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Gene Information

Human
Gene Name:	PTPRR
Uniprot:	Q15256
Entrez:	5801

Family

Belongs to:

protein-tyrosine phosphatase family

Alternative Names

Ch-1 PTPase; ch-1PTPase; DKFZp781C1038; EC 3.1.3.48; ECPTP; EC-PTP; FLJ34328; MGC131968; MGC148170; NC-PTPCOM1; PCPTP1; protein tyrosine phosphatase Cr1PTPase; protein tyrosine phosphatase, receptor type, R; protein-tyrosine phosphatase NC-PTPCOM1; Protein-tyrosine phosphatase PCPTP1; PTPBR7; PTPRQ; PTP-SL; receptor-type tyrosine-protein phosphatase R; R-PTP-R

Molecular Weight

Mass (kDA):
73.834 kDA

Genomic Context


Human

Location:	12q15
Sequence:	12; NC_000012.12 (70638073..70920738, complement)

Tissue Specificity

Expressed in brain, placenta, small intestine, stomach, uterus and weakly in the prostate. Isoform alpha has been observed only in the brain. Isoform gamma is expressed in brain, placenta and uterus. Isoform delta is expressed in brain, kidney, placenta, prostate, small intestine and uterus.

Subcellular Localizations

[Isoform Alpha]: Cell membrane; Single-pass type I membrane protein.; [Isoform Delta]: Cytoplasm, perinuclear region. Locates to the perinuclear areas within the cytoplasm.; [Isoform Gamma]: Cytoplasm, perinuclear region. Locates to the perinuclear areas within the cytoplasm.

Diseases

Posttransfusion Purpura
Malignant Neoplasms
Neoplasms
Neoplasm Metastasis
Ataxia
Cerebellar Ataxia
Diabetes Mellitus
Mental Disorders
Major Depressive Disorder
Diabetes Mellitus, Non-insulin-dependent
Colorectal Neoplasms
Depressive Disorder
Leukemia, Myelocytic, Acute

Colorectal Cancer
Tissue Adhesions
Leukemia
Adenoma
Malignant Neoplasm Of Breast
Metastatic Malignant Neoplasm To The Liver
Neoplasm Invasiveness

Interacting Proteins

ERBB2
INSR
MAPK1
MAPK14

Pathways

Translation
Dna Methylation
Localization
Ion Homeostasis
Methylation
Cell Motility
Calcium Ion Homeostasis
Secretion
Transport
Cell Adhesion
Cell Proliferation
Insulin Secretion
Short-term Memory

Dentinogenesis
Coagulation
Cell Cycle
Locomotion
Cell Differentiation
Long-term Memory
Angiogenesis

PTMs

Phosphorylation

Dephosphorylation

Methylation

Research Areas

Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PTPRR

References

PMID: 7557444 by Shiozuka K., et al. Cloning and expression of PCPTP1 encoding protein tyrosine phosphatase.

PMID: 10705342 by Augustine K.A., et al. Protein tyrosine phosphatase (PC12, Br7,Sl) family: expression characterization in the adult human and mouse.