PTPN23 Antibodies

AND PTPN23 ELISA kits, PTPN23 Proteins

Many biological assays use antibodies to detect PTPN23, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PTPN23 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PTPN23 antibodies...

We validate the specificity of these antibodies to PTPN23 by testing them on tissues known to express PTPN23 positively and negatively. Browse below to find the PTPN23 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PTPN23 Infographic by Boster Bio

All PTPN23 Products

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Anti-PTPN23 Antibody

Mouse, Rat

IHC, WB

$405
Cat # A05909
100ul

PTPN23 Overview

Facts about Tyrosine-protein phosphatase non-receptor type 23.

PTPN23 3D structure. Source: alphafold

Tyrosine-protein phosphatase non-receptor type 23 (PTPN23)

Plays a role in sorting of endocytic ubiquitinated cargos to multivesicular bodies (MVBs) through its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and maybe also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity.

Plays a role in ciliogenesis. .

Gene Information

Human
Gene Name:	PTPN23
Uniprot:	Q9H3S7
Entrez:	25930

Family

Belongs to:

protein-tyrosine phosphatase family

Alternative Names

EC 3.1.3.48; HDPTP; HD-PTPDKFZp564F0923; His domain-containing protein tyrosine phosphatase; His-domain protein tyrosine phosphatase; KIAA1471DKFZP564F0923; Protein tyrosine phosphatase TD14; protein tyrosine phosphatase, non-receptor type 23; PTP-TD14; tyrosine-protein phosphatase non-receptor type 23

Molecular Weight

Mass (kDA):
178.974 kDA

Genomic Context


Human

Location:	3p21.31
Sequence:	3; NC_000003.12 (47381001..47413435)

Subcellular Localizations

Nucleus. Cytoplasm. Cytoplasmic vesicle. Endosome. Cytoplasm, cytoskeleton, cilium basal body. Early endosome.

Diseases

Neoplasms
Posttransfusion Purpura
Tissue Adhesions
Tumor Angiogenesis
Malignant Neoplasms
Cell Invasion
Neoplasm Invasiveness
Malignant Neoplasm Of Urinary Bladder
Carcinoma
Immunologic Deficiency Syndromes
Hiv Infections
Neoplasm Metastasis

Malignant Neoplasm Of Breast
Malignant Neoplasm Of Lung
Parkinson Disease
Sarcoidosis
Chimera Disorder
Pathologic Neovascularization

Interacting Proteins

CEP55
CHMP4B
GRAP2
Grap2
GRB2

NOTCH2NL
PDCD6
PSMA3
PTK2
SH3GL2

TRIM27
TSG101

Pathways

Cell Migration
Cell Motility
Angiogenesis
Pathogenesis
Cell Adhesion
Body Morphogenesis
Immune Response
Endocytosis
Localization
Endothelial Cell Migration
Cell Death

Regulation Of Cell Motility
Regulation Of Cell Migration
Cell Growth
Regulation Of Immune Response
Wound Healing
Rna Interference

PTMs

Phosphorylation

Dephosphorylation

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PTPN23

References

PMID: 11095967 by Toyooka S., et al. HD-PTP: a novel protein tyrosine phosphatase gene on human chromosome 3p21.3.

PMID: 18434552 by Doyotte A., et al. The Bro1-related protein HD-PTP/PTPN23 is required for endosomal cargo sorting and multivesicular body morphogenesis.