This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
CLIC4 Antibodies
AND CLIC4 ELISA kits, CLIC4 Proteins
Many biological assays use antibodies to detect CLIC4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CLIC4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CLIC4 antibodies...
Previous: SEPTIN9
Next: NIPSNAP3A
CLIC4 Infographic by Boster Bio
All CLIC4 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M03210
100 μl/vial
Cat # M03210
100 μl/vial
CLIC4 Overview
Facts about Chloride intracellular channel protein 4.
Chloride intracellular channel protein 4 (CLIC4)
Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH.
Membrane insertion appears to be redox-regulated and might occur only under oxydizing problems. Promotes cell- surface expression of HRH3.
Gene Information
| Human | |
|---|---|
| Gene Name: | CLIC4 |
| Uniprot: | Q9Y696 |
| Entrez: | 25932 |
Family
| Belongs to: |
|---|
| chloride channel CLIC family |
Alternative Names
chloride intracellular channel 4 like; chloride intracellular channel 4; chloride intracellular channel protein 4; CLIC4L; DKFZp566G223; FLJ38640; H1; huH1; Intracellular chloride ion channel protein p64H1; MTCLIC; P64H1
Molecular Weight
Mass (kDA):
28.772 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p36.11 |
| Sequence: | 1; NC_000001.11 (24745447..24844321) |
Tissue Specificity
Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression is prominent in heart, kidney, placenta and skeletal muscle.
Subcellular Localizations
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic vesicle membrane; Single-pass membrane protein. Nucleus matrix. Cell membrane; Single-pass membrane protein. Mitochondrion. Cell junction. Colocalized with AKAP9 at the centrosome and midbody. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles.
Diseases
- Malignant Neoplasms
- Neoplasms
- Tumor Angiogenesis
- Cell Transformation, Neoplastic
- Carcinoma
- Pathologic Neovascularization
- Malignant Paraganglionic Neoplasm
- Growth Arrest
- Skin Neoplasms
- Malignant Neoplasm Of Breast
- Inflammation
Pathways
- Localization
- Cell Proliferation
- Angiogenesis
- Pathogenesis
- Transport
- Cell Cycle
- Cell Migration
- Cell Motility
- Tube Formation
- Nuclear Import
- Cell Division
- Cell Differentiation
- Response To Stress
PTMs
- Phosphorylation
- Nitrosylation
- Dephosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CLIC4
bosterbio.com/bosterbio-gene-info-cards/CLIC4
References
PMID: 10070163 by Edwards J.C.; A novel p64-related Cl- channel: subcellular distribution and nephron segment-specific expression.
PMID: 10191309 by Chuang J.Z., et al. A 29 kDa intracellular chloride channel p64H1 is associated with large dense-core vesicles in rat hippocampal neurons.