PTPN14 Antibodies

AND PTPN14 ELISA kits, PTPN14 Proteins

Many biological assays use antibodies to detect PTPN14, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PTPN14 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PTPN14 antibodies...

We validate the specificity of these antibodies to PTPN14 by testing them on tissues known to express PTPN14 positively and negatively. Browse below to find the PTPN14 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PTPN14 Infographic by Boster Bio

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Anti-PTN14 PTPN14 Antibody

Human, Mouse

ELISA, WB

$380
Cat # A03313
100ul

PTPN14 Overview

Facts about Tyrosine-protein phosphatase non-receptor type 14.

PTPN14 3D structure. Source: alphafold

Tyrosine-protein phosphatase non-receptor type 14 (PTPN14)

Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell- matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial- mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions.

Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a mobile density-dependent method. May function as a tumor suppressor.

Gene Information

Human
Gene Name:	PTPN14
Uniprot:	Q15678
Entrez:	5784

Family

Belongs to:

protein-tyrosine phosphatase family

Alternative Names

EC 3.1.3; EC 3.1.3.48; MGC126803; PEZ; PEZcytoskeletal-associated protein tyrosine phosphatase; protein tyrosine phosphatase, non-receptor type 14; Protein-tyrosine phosphatase pez; PTP36; PTPN14; tyrosine-protein phosphatase non-receptor type 14

Molecular Weight

Mass (kDA):
135.261 kDA

Genomic Context


Human

Location:	1q32.3-q41
Sequence:	1; NC_000001.11 (214348700..214551677, complement)

Tissue Specificity

Ubiquitous.

Subcellular Localizations

Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Translocation into the nucleus is associated with induction of cell proliferation. Partially colocalized with actin filaments at the plasma membrane.

Diseases

Malignant Neoplasms
Neoplasms
Neoplasm Metastasis
Tumor Angiogenesis
Colorectal Cancer
Tissue Adhesions
Mammary Neoplasms
Cell Transformation, Neoplastic
Lung Neoplasms
Colorectal Neoplasms
Hereditary Hemorrhagic Telangiectasia
Atresia

Metastatic Malignant Neoplasm To The Liver
Pulmonary Arteriovenous Malformation
Neoplasm Invasiveness
Arteriovenous Malformation
Malignant Neoplasm Of Lung
Immunologic Deficiency Syndromes
Dysplasia

Interacting Proteins

YAP1

Pathways

Cell Proliferation
Localization
Angiogenesis
Transport
Cell Cycle
Cell Growth
Cell Adhesion
Regulation Of Cell Cycle
Cell Activation
Vesicle Transport
Cell Migration
T Cell Activation
Lymphangiogenesis

Reverse Transcription
Translation
Organ Development
Cell Motility
Cell-substrate Adhesion
Cell Communication
Organ Formation

PTMs

Phosphorylation

Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PTPN14

References

PMID: 7733990 by Smith A.L., et al. Pez: a novel human cDNA encoding protein tyrosine phosphatase- and ezrin-like domains.

PMID: 10934049 by Wadham C., et al. Translocation of protein tyrosine phosphatase Pez/PTPD2/PTP36 to the nucleus is associated with induction of cell proliferation.