PTPN11 Antibodies

AND PTPN11 ELISA kits, PTPN11 Proteins

Many biological assays use antibodies to detect PTPN11, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PTPN11 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PTPN11 antibodies...

We validate the specificity of these antibodies to PTPN11 by testing them on tissues known to express PTPN11 positively and negatively. Browse below to find the PTPN11 antibody that suites your experiment. We have 16 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PTPN11 Infographic by Boster Bio

All PTPN11 Products

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Product

Figures

Specificity

Applications

Price

Anti-SHP2/PTPN11 Antibody Picoband®

2 Q&As

Human, Mouse, Rat

IHC, WB

$370
Cat # PB9675
100 μg/vial

Anti-SHP2/PTPN11 Antibody Picoband®

Human, Mouse, Rat

IHC, WB

$370
Cat # PA1114
100 μg/vial

Anti-SHP2/PTPN11 Antibody Picoband®

3 Q&As

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # PA1860
100 μg/vial

Anti-Phospho-SHP2 (Y542) PTPN11 Rabbit Monoclonal Antibody

Human, Mouse

IP, IF, ICC, WB

$370
Cat # P00150
100 μl

Anti-SHP2 PTPN11 Rabbit Monoclonal Antibody

Human, Mouse, Rat

IP, WB

$370
Cat # M00150-1
100 μl

Anti-SHP2 PTPN11 Rabbit Monoclonal Antibody

Human

IP, IF, IHC, ICC, WB

$370
Cat # M00150
100 μl

Anti-SHP-2 (Ab-542) PTPN11 Antibody

Human, Mouse, Rat

IF, IHC, WB

$360
Cat # A00150
100 µl

Anti-SHP2/PTPN11 Antibody Picoband® (monoclonal, 2E6)

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # M00150-2
100 μg/vial

SHP-2 Colorimetric Cell-Based ELISA Kit

Human, Mouse, Rat

ELISA

$480
Cat # EKC1522
1 kit, containing one 96-well plate and all necessary reagents

SHP-2 (Phospho-Tyr542) Colorimetric Cell-Based ELISA Kit

Human, Mouse, Rat

ELISA

$540
Cat # EKC1956
1 kit, containing two 96-well plates and all necessary reagents

SHP-2 (Phospho-Tyr580) Colorimetric Cell-Based ELISA Kit

Human, Mouse, Rat

ELISA

$540
Cat # EKC1957
1 kit, containing two 96-well plates and all necessary reagents

Anti-SHP-2 (S350) PTPN11 Antibody

Human, Mouse, Rat

IHC, WB

$405
Cat # A00150S350
100ul

Anti-SHP-2 (phospho-Y542) PTPN11 Antibody

Human, Mouse, Rat

IHC, WB

$482
Cat # A00150Y542
100ul

Anti-SHP2 (Phospho-Y542) PTPN11 Antibody

Human, Mouse

IP, ICC, WB

$405
Cat # A00150Y542-1
100ul

Anti-Phospho-SH-PTP2 (Y580) PTPN11 Antibody

Human, Mouse, Rat

ELISA, IHC, WB

$380
Cat # A00150Y580
100ul

Human PTPN11 Recombinant Protein

SDS-PAGE

$265
Cat # PROTQ06124
Starting from 10ug

PTPN11 Overview

Facts about Tyrosine-protein phosphatase non-receptor type 11.

PTPN11 3D structure. Source: alphafold

Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)

Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to take part in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway (PubMed:28074573).

Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at'Tyr-722' resulting in stimulatation of its RhoA binding activity.

Gene Information

Human
Gene Name:	PTPN11
Uniprot:	Q06124
Entrez:	5781

Family

Belongs to:

protein-tyrosine phosphatase family

Alternative Names

BPTP3; EC 3.1.3.48; MGC14433; protein tyrosine phosphatase, non-receptor type 11; protein tyrosine phosphatase-2; Protein-tyrosine phosphatase 1D; Protein-tyrosine phosphatase 2C; PTP1D; PTP-1D; PTP2C; PTP-2C; PTP2CNS1; PTPN11; SHP2; SHP-2; SHP2CFC; SHPTP2; SH-PTP2; SH-PTP2Noonan syndrome 1; SH-PTP3; tyrosine-protein phosphatase non-receptor type 11

Molecular Weight

Mass (kDA):
68.011 kDA

Genomic Context


Human

Location:	12q24.13
Sequence:	12; NC_000012.12 (112418915..112509918)

Tissue Specificity

Widely expressed, with highest levels in heart, brain, and skeletal muscle.

Subcellular Localizations

Cytoplasm. Nucleus.

Diseases

Noonan Syndrome
Leukemia
Malignant Neoplasms
Neoplasms
Tissue Adhesions
Dwarfism
Congenital Heart Defects
Leopard Syndrome
Myelomonocytic Leukemia
Juvenile Myelomonocytic Leukemia
Posttransfusion Purpura
Hypertrophy
Cardiomyopathies

Hypertrophic Cardiomyopathy
Myeloid Leukemia
Cell Transformation, Neoplastic
Stenosis
Neurofibromatosis 1
Carcinoma
Leukemia, Myelocytic, Acute

Interacting Proteins

AR
CCKBR
CD244
CD33
DDR1

EGFR
EPHA2
ERBB2
FLT1
FRS2

GAB1
GAB2
GRB2
IGF1R
INSR

IRS1
Irs1
KIR2DL3
KIT
MET

MPZL1
PDCD1
PDGFRB
PECAM1
PXN

RPIA
Sirpa
TRIM32

Pathways

Pathogenesis
Cell Proliferation
Cell Activation
Cell Growth
Cell Adhesion
Localization
Cell Migration
Secretion
Cell Death
Cell Cycle
Cell Differentiation
T Cell Activation
Hypersensitivity

Cell Development
Cell Motility
Hyperphosphorylation
Chemotaxis
Angiogenesis
B Cell Activation
Virulence

PTMs

Phosphorylation
Dephosphorylation
Oxidation
Glycosylation
Methylation
Cleavage
Myristoylation
Nitration
Biotinylation

Reduction
Acetylation
Demethylation
Nitrosylation
Glutathionylation
Deamination
Ribosylation
Palmitoylation
Deglycosylation

Research Areas

Angiogenesis
Cancer
Cell Biology
Lipid and Metabolism
Phospho-Specific

Signal Transduction
Tyrosine Kinases

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PTPN11

References

PMID: 1281790 by Adachi M., et al. Molecular cloning of a novel protein-tyrosine phosphatase SH-PTP3 with sequence similarity to the src-homology region 2.

PMID: 1280823 by Freeman R.M. Jr., et al. Identification of a human src homology 2-containing protein-tyrosine- phosphatase: a putative homolog of Drosophila corkscrew.