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- Table of Contents
Facts about Protein tyrosine phosphatase type IVA 3.
May be involved in the development of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II. .
Human | |
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Gene Name: | PTP4A3 |
Uniprot: | O75365 |
Entrez: | 11156 |
Belongs to: |
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protein-tyrosine phosphatase family |
PRL3; PRL-3; PRL3EC 3.1.3.48; PRL-3potentially prenylated protein tyrosine phosphatase; PRL-Rprotein tyrosine phosphatase type IVA 3; protein tyrosine phosphatase type IVA, member 3; Protein-tyrosine phosphatase 4a3; Protein-tyrosine phosphatase of regenerating liver 3; PTP4A3
Mass (kDA):
19.535 kDA
Human | |
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Location: | 8q24.3 |
Sequence: | 8; NC_000008.11 (141391995..141432454) |
Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis.
Cell membrane. Early endosome.
PMID: 9633825 by Dayton M.A., et al. Multiple phosphotyrosine phosphatase mRNAs are expressed in the human lung fibroblast cell line WI-38.
PMID: 11355880 by Matter W.F., et al. Role of PRL-3, a human muscle-specific tyrosine phosphatase, in angiotensin-II signaling.