Prostaglandin G/H synthase 1 (PTGS1)

Converts arachidonate to prostaglandin H2 (PGH2), a dedicated step in prostanoid synthesis. Involved from the constitutive production of prostanoids in particular in the stomach and platelets.

In gastric epithelial cells, it's a key step in the creation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an significant role in cytoprotection. In platelets, it's involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.