Prostaglandin E synthase 3 (PTGES3)

Cytosolic prostaglandin synthase which catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone which localizes to genomic response elements within an hormone-dependent fashion and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419).

Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 into the HSP90 pathway (PubMed:24711448). .