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- Table of Contents
Facts about Prostaglandin E2 receptor EP3 subtype.
Receptor for prostaglandin E2 (PGE2) (PubMed:8307176, PubMed:7883006, PubMed:8117308, PubMed:8135729, PubMed:7981210).
The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G(I) proteins, as well as an elevation of intracellular calcium (PubMed:7883006, PubMed:8117308, PubMed:8135729, PubMed:7981210).Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation.
Human | |
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Gene Name: | PTGER3 |
Uniprot: | P43115 |
Entrez: | 5733 |
Belongs to: |
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G-protein coupled receptor 1 family |
EP3; EP3EP3e; EP3-I; EP3-II; EP3-III; EP3-IV; MGC141828; MGC141829; MGC27302; PGE receptor EP3 subtype; PGE receptor, EP3 subtype; PGE2 receptor EP3 subtype; PGE2-R; prostaglandin E receotor EP3 subtype 3 isoform; prostaglandin E receptor 3 (subtype EP3); prostaglandin E2 receptor EP3 subtype; prostaglandin receptor (PGE-2); Prostanoid EP3 receptor; PTGER3
Mass (kDA):
43.31 kDA
Human | |
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Location: | 1p31.1 |
Sequence: | 1; NC_000001.11 (70852358..71047816, complement) |
Detected in kidney (PubMed:8117308, PubMed:8135729). Expressed in small intestine, heart, pancreas, gastric fundic mucosa, mammary artery and pulmonary vessels.
Cell membrane; Multi-pass membrane protein.
PMID: 8307176 by Adam M., et al. Cloning and expression of three isoforms of the human EP3 prostanoid receptor.
PMID: 7883006 by Schmid A., et al. Splice variants of the human EP3 receptor for prostaglandin E2.