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Ptbp2 Antibodies
AND Ptbp2 ELISA kits, Ptbp2 Proteins
Many biological assays use antibodies to detect Ptbp2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Ptbp2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Ptbp2 antibodies...
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Ptbp2 Infographic by Boster Bio
All Ptbp2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A05020-2
100 μg/vial
Cat # A05020-2
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M05020-1
100 μg/vial
Cat # M05020-1
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M05020-2
100 μg/vial
Cat # M05020-2
100 μg/vial
Ptbp2 Overview
Facts about Polypyrimidine tract-binding protein 2.
Polypyrimidine tract-binding protein 2 (Ptbp2)
RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the capacity of NOVA1 to activate exon selection.
In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation. .
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Ptbp2 |
| Uniprot: | Q91Z31 |
| Entrez: | 56195 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
brPTB; FLJ34897; neural polypyrimidine tract binding protein; Neural polypyrimidine tract-binding protein; Neurally-enriched homolog of PTB; nPTB; nPTB6; nPTB7; nPTB8; polypyrimidine tract binding protein 2; polypyrimidine tract-binding protein 2; PTB-like protein; PTBPTBLPnPTB5; splicing regulator
Molecular Weight
Mass (kDA):
57.489 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 3|3 G1 |
| Sequence: | 3; |
Tissue Specificity
Mainly expressed in brain, including cerebellum, brainstem, spinal cord, and hypothalamus. Also expressed in the peripheral nervous system and neural crest derivatives, including the dorsal root and trigeminal ganglia, the cochlear spiral and intestinal ganglion cells, and the adrenal medulla. Also detected to a lower extent in testis, heart, liver, lung, skeletal muscle and thymus (at protein level).
Diseases
- Neuroblastoma
- Nervousness
- Glioma
- Obesity
- Timothy Syndrome
- Hereditary Diseases
- Long Qt Syndrome
- Neurodegenerative Disorders
- Nerve Degeneration
- Tdp-43 Proteinopathies
- Tissue Adhesions
- Diabetes Mellitus
- Progressive Supranuclear Palsy
Pathways
- Brain Development
- Neurogenesis
- Cell Differentiation
- Synapse Maturation
- Transport
- Cell Proliferation
- Cell Migration
- Stem Cell Differentiation
- Muscle Contraction
- Localization
- Rna Splicing
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Ptbp2
bosterbio.com/bosterbio-gene-info-cards/Ptbp2
References
PMID: 10829067 by Polydorides A.D., et al. A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing.
PMID: 14667811 by Rahman L., et al. Evolutionary conservation of a 2-kb intronic sequence flanking a tissue-specific alternative exon in the PTBP2 gene.