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PSMD2 Antibodies
AND PSMD2 ELISA kits, PSMD2 Proteins
Many biological assays use antibodies to detect PSMD2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PSMD2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PSMD2 antibodies...
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PSMD2 Infographic by Boster Bio
All PSMD2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA
$480
Cat # EKC1790
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1790
1 kit, containing one 96-well plate and all necessary reagents
Dog, Human, Monkey, Mouse, Rat
IF, IHC, WB
$523
Cat # M06642
100 µl
Cat # M06642
100 µl
PSMD2 Overview
Facts about 26S proteasome non-ATPase regulatory subunit 2.
26S proteasome non-ATPase regulatory subunit 2 (PSMD2)
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required.
Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. .
Gene Information
| Human | |
|---|---|
| Gene Name: | PSMD2 |
| Uniprot: | Q13200 |
| Entrez: | 5708 |
Family
| Belongs to: |
|---|
| proteasome subunit S2 family |
Alternative Names
26S proteasome regulatory subunit RPN1; 26S proteasome regulatory subunit S2; MGC14274,55.11 protein; P97; proteasome (prosome, macropain) 26S subunit, non-ATPase, 2; Protein 55.11; Rpn1; S226S proteasome non-ATPase regulatory subunit 2; TNFR-associated protein 2; TRAP226S proteasome subunit p97; tumor necrosis factor receptor-associated protein 2; Tumor necrosis factor type 1 receptor-associated protein 2
Molecular Weight
Mass (kDA):
100.2 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q27.1 |
| Sequence: | 3; NC_000003.12 (184299241..184309050) |
Tissue Specificity
Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung and placenta.
Diseases
- Malignant Neoplasms
- Malignant Neoplasm Of Breast
- Lung Diseases
- Malignant Neoplasm Of Lung
- Neoplasms
- Familial Mediterranean Fever
- Sarcoidosis
- Sciatic Nerve Injury
- Mammary Neoplasms
- Cardiac Failure Chronic
- Adenocarcinoma
Interacting Proteins
- ADRM1
- BAG1
- Hacd3
- MLF1
- PSMC1
- PSMC2
- PSMC5
- PSMD4
- UBLCP1
- UCHL5
Pathways
- Proteolysis
- Cell Death
- Cell Adhesion
- Mitosis
- Metaphase
- Muscle Atrophy
- Regeneration
- Coagulation
- Translation
PTMs
- Cleavage
Research Areas
- Cell Cycle and Replication
- Neuroscience
- Ubiquitin Proteasome Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PSMD2
bosterbio.com/bosterbio-gene-info-cards/PSMD2
References
PMID: 8774743 by Tsurumi C., et al. cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis- factor-receptor-associated protein-2/55.11.
PMID: 9126987 by Dunbar J.D., et al. Two-hybrid cloning of a gene encoding TNF receptor-associated protein 2, a protein that interacts with the intracellular domain of the type 1 TNF receptor: identity with subunit 2 of the 26S protease.