26S proteasome regulatory subunit 6A (PSMC3)

Part of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by eliminating misfolded or damaged proteins, which could impair cellular functions, and by eliminating proteins whose functions are no longer required.

Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are simultaneously translocated into a proteolytic room and degraded into peptides.