Proteasome subunit beta type-5 (PSMB5)

Component of the 20S core proteasome complex involved in the proteolytic degradation of the majority of intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles.

Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays an integral role in the maintenance of protein homeostasis by eliminating misfolded or damaged proteins that could impair cellular functions, and by eliminating proteins whose functions are no longer required.