PSMB8 Antibodies

AND PSMB8 ELISA kits, PSMB8 Proteins

Many biological assays use antibodies to detect PSMB8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PSMB8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PSMB8 antibodies...

We validate the specificity of these antibodies to PSMB8 by testing them on tissues known to express PSMB8 positively and negatively. Browse below to find the PSMB8 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PSMB8 Infographic by Boster Bio

All PSMB8 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-PSMB8 / LMP7 Monoclonal Antibody

4 Q&As

Human, Mouse, Rat

Flow Cytometry, IP, IF, IHC, ICC, WB

$370
Cat # M02188-2
100 μl

Anti-Proteasome subunit beta type-8 PSMB8 Antibody

Human, Mouse, Rat

IF, IHC, ICC, WB

$405
Cat # A02188-1
100ul

Anti-Proteasome subunit beta type-8 PSMB8 Antibody

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$405
Cat # A02188-2
100ul

PSMB8 (NM_004159) Human Recombinant Protein

$813
Cat # PROTP28062
20 µg

PSMB8 (NM_004159) Human Over-expression Lysate

Human

$628
Cat # LS005696
100 µg

PSMB8 Overview

Facts about Proteasome subunit beta type-8.

PSMB8 3D structure. Source: alphafold

Proteasome subunit beta type-8 (PSMB8)

This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues.

Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis through the degradation of the apoptotic inhibitor MCL1.

Gene Information

Human
Gene Name:	PSMB8
Uniprot:	P28062
Entrez:	5696

Family

Belongs to:

peptidase T1B family

Alternative Names

ALDD; beta5i; D6S216E; EC 3.4.25.1; JMP; LMP7; LMP7MGC1491; Low molecular mass protein 7; low molecular weight protein 7; Macropain subunit C13; Multicatalytic endopeptidase complex subunit C13; NKJO; protease component C13; proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctionalpeptidase 7); proteasome catalytic subunit 3i; Proteasome Component C13; proteasome subunit beta 5i; proteasome subunit beta type-8; Proteasome subunit beta-5i; Proteasome Subunit Y2; proteasome-related gene 7; PSMB5i; PSMB5iD6S216; PSMB8; Really interesting new gene 10 protein; RING10; RING10prote

Molecular Weight

Mass (kDA):
30.354 kDA

Genomic Context


Human

Location:	6p21.32
Sequence:	6; NC_000006.12 (32840717..32844679, complement)

Subcellular Localizations

Cytoplasm. Nucleus.

Diseases

Inflammation
Lipodystrophy
Atrophy
Muscle Contracture
Panniculitis
Anemia
Dermatologic Disorders
Exanthema
Muscular Atrophy
Autoimmune Reaction
Clubbing
Swine Diseases

Malignant Neoplasms
Clubbed Fingers
Microcytic Anemia
Arthritis
Inflammatory Response
Acquired Partial Lipodystrophy
Insulin Resistance

Pathways

Immune Response
Transport
Pathogenesis
Tropism
Inflammatory Response
Cell Cycle
Proteasome Assembly
Muscle Atrophy
Electron Transport
Cellular Homeostasis
Proteolysis
Hypersensitivity
Response To Virus

Regulation Of Gene Expression
Oxidative Phosphorylation
Spermatogenesis
Chemotaxis
Mrna Processing
Glycosylation
Ion Transport

PTMs

Cleavage

Ubiquitination

Phosphorylation

Research Areas

Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PSMB8

References

PMID: 8458375 by Glynne R., et al. The major histocompatibility complex-encoded proteasome component LMP7: alternative first exons and post-translational processing.

PMID: 1453454 by Beck S., et al. DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing.