Proteasome subunit beta type-4 (PSMB4)

Part of the 20S core proteasome complex involved in the proteolytic degradation of the majority of intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles.

Associated with two 19S regulatory particles, forms the 26S proteasome and so participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays an integral role in the maintenance of protein homeostasis by removing misfolded or damaged proteins which could impair cellular functions, and by removing proteins whose functions are no longer required.