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PSENEN Antibodies
AND PSENEN ELISA kits, PSENEN Proteins
Many biological assays use antibodies to detect PSENEN, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PSENEN in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PSENEN antibodies...
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PSENEN Infographic by Boster Bio
All PSENEN Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M04504-1
100 μl/vial
Cat # M04504-1
100 μl/vial
PSENEN Overview
Facts about Gamma-secretase subunit PEN-2.
Gamma-secretase subunit PEN-2 (PSENEN)
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable).
PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111). .
Gene Information
| Human | |
|---|---|
| Gene Name: | PSENEN |
| Uniprot: | Q9NZ42 |
| Entrez: | 55851 |
Family
| Belongs to: |
|---|
| PEN-2 family |
Alternative Names
gamma-secretase subunit PEN-2; MSTP064; PEN-2; PEN2hematopoietic stem/progenitor cells protein MDS033; presenilin enhancer 2 homolog (C. elegans); Presenilin enhancer protein 2; PSENEN
Molecular Weight
Mass (kDA):
12.029 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.12 |
| Sequence: | 19; NC_000019.10 (35745651..35747519) |
Tissue Specificity
Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain.
Subcellular Localizations
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, Golgi stack membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
Diseases
- Alzheimer's Disease
- Alzheimer Disease, Familial
- Plaque, Amyloid
- Hidradenitis
- Hidradenitis Suppurativa
- Acne
- Neurodegenerative Disorders
- Dementia
- Neurofibrillary Tangles
- Shwachman Syndrome
- Senile Plaques
- Mutation Abnormality
- Amnesia
Interacting Proteins
- FTL
- NCSTN
- PSEN1
- TMED10
Pathways
- Pathogenesis
- Proteolysis
- Localization
- Rna Interference
- Glycosylation
- Cell Death
- Transport
- Secretory Pathway
- Aging
- Secretion
- Regulation Of Cell Death
- Transposition
PTMs
- Cleavage
- Glycosylation
- Phosphorylation
Research Areas
- Growth and Development
- Neurodegeneration
- Neuronal Cell Markers
- Neuroscience
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PSENEN
bosterbio.com/bosterbio-gene-info-cards/PSENEN
References
PMID: 12198112 by Steiner H., et al. PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin.
PMID: 12110170 by Francis R., et al. aph-1 and pen-2 are required for Notch pathway signaling, gamma- secretase cleavage of betaAPP, and presenilin protein accumulation.