PSD4 Antibodies

AND PSD4 ELISA kits, PSD4 Proteins

Many biological assays use antibodies to detect PSD4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PSD4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PSD4 antibodies...

We validate the specificity of these antibodies to PSD4 by testing them on tissues known to express PSD4 positively and negatively. Browse below to find the PSD4 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PSD4 Infographic by Boster Bio

All PSD4 Products

Product

Figures

Specificity

Applications

Price

Anti-PSD4 Antibody

Human

ELISA, WB

$380
Cat # A13179
100ul

PSD4 (NM_012455) Human Over-expression Lysate

Human

$628
Cat # LS023550
100 µg

PSD4 Overview

Facts about PH and SEC7 domain-containing protein 4.

PSD4 3D structure. Source: alphafold

PH and SEC7 domain-containing protein 4 (PSD4)

Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. During ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells.

Involved in membrane recycling. Interacts with different phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5- bisphosphate and phosphatidylinositol 4,5-bisphosphate.

Gene Information

Human
Gene Name:	PSD4
Uniprot:	Q8NDX1
Entrez:	23550

Family

Belongs to:

No superfamily

Alternative Names

pleckstrin and Sec7 domain containing 4

Molecular Weight

Mass (kDA):
116.249 kDA

Genomic Context


Human

Location:	2q14.1
Sequence:	2; NC_000002.12 (113157399..113209391)

Tissue Specificity

Widely expressed. Highest levels of expression are found in placenta, pancreas, spleen, thymus and peripheral blood.

Subcellular Localizations

Cell membrane. Cell projection, ruffle membrane. In interphase associated with the plasma membrane, in particular with membrane ruffling regions (PubMed:23603394). Accumulates in dynamic actin-rich membrane ruffles and microvilli-like structures (PubMed:12082148). Recruited to membranes via phosphatidylinositol phosphate-binding (Probable).

Diseases

Nerve Damage
Demyelinating Polyneuropathy
Polyneuropathy
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
Facial Nerve Injuries
Demyelination
Crushing Sensation

Demyelinating Diseases

Interacting Proteins

LDLRAP1

Pathways

Regeneration

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PSD4

References

PMID: 12082148 by Derrien V., et al. A conserved carboxy-terminal domain of EFA6-family ARF6-guanine nucleotide exchange factors induces lengthening of microvilli-like membrane protrusions.

PMID: 21458045 by Paul P., et al. A Genome-wide multidimensional RNAi screen reveals pathways controlling MHC class II antigen presentation.