PSCA Antibodies

Prostate stem cell antigen (PSCA)

May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro.

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Gene Information

Human
Gene Name:	PSCA
Uniprot:	O43653
Entrez:	8000

Family

Belongs to:
No superfamily

Alternative Names

PRO232; prostate stem cell antigen; PSCA

Molecular Weight

Mass (kDA):
11.959 kDA

Genomic Context

Human
Location:	8q24.3
Sequence:	8; NC_000008.11 (142670297..142682725)

Tissue Specificity

Highly expressed in prostate (basal, secretory and neuroendocrine epithelium cells). Also found in bladder (transitional epithelium), placenta (trophoblasts), stomach (neuroendocrine cells), colon (neuroendocrine cells) and kidney (collecting ducts). Overexpressed in prostate cancers and expression is correlated with tumor stage, grade and androgen- independence. Highly expressed in prostate cancer bone metastases. Expressed in gastric epithelial cells, mainly in the isthmus (at protein level). Not detected in normal intestinal epithelium (at protein level). Expressed in brain cortex; expression is significantly increased in the front cortex of Alzheimer disease patients.

Subcellular Localizations

Cell membrane; Lipid-anchor, GPI-anchor.

Diseases

• Malignant Neoplasms
• Neoplasms
• Malignant Neoplasm Of Prostate
• Prostatic Neoplasms
• Carcinoma
• Neoplasm Metastasis
• Adenocarcinoma
• Malignant Neoplasm Of Stomach
• Carcinogenesis
• Stomach Neoplasms
• Malignant Neoplasm Of Pancreas
• Malignant Paraganglionic Neoplasm

• Pancreatic Neoplasm
• Bladder Neoplasm
• Cell Transformation, Neoplastic
• Malignant Neoplasm Of Urinary Bladder
• Hyperplasia
• Prostatic Hyperplasia
• Intraepithelial Neoplasia

Pathways

• Immune Response
• Cell Growth
• Pathogenesis
• Virulence
• Conjugation
• Localization
• Cell Cycle
• Cell Differentiation
• Methylation
• Reverse Transcription
• Translation
• Oncogenesis
• Cell Proliferation

• Dna Methylation
• Regeneration
• Cell Death
• Secretion
• Transport
• Cell Adhesion
• Cell Activation

PTMs

• Methylation
• Phosphorylation

• Glycosylation
• Reduction

• Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PSCA

Best Uses Of The PSCA Marker

If you're interested in using PSCA to perform molecular diagnostics, take a look at this article. You'll learn about the Boster Bio's primary-secondary-ABC system, PSCA-specific modular systems, and more. You'll also learn about the PSCA genetic variations which are believed to increase the susceptibility to certain kinds of cancer. We'll also go over the Super Vision Detection Kits, as well in the PSCA-specific modular system.

Super Vision Detection kits

The SuperVision Detection kit is one of Boster Bio's most innovative methods for identifying proteins. The combination of avidins, signal molecules (typically Horseradish Peroxide or HRP), provides highly sensitive and specific staining of the immunohistochemical system. Each kit includes all the necessary components for one or more detection. Boster Bio also offers credits to share your results.

PSCA-specific modular system

The PSCA-specific modular system, an ingenuous immunotherapy for cancerpatients, can slow the growth of s.c. tumors and trigger T cell-mediated killing. It is able to replace conventional bsAbs, as well as allow for flexible redirection to T cells. The modular system is PSCA-specific and can be utilized immediately following the construction. This permits targeted-specific cytotoxicity.

Genetic variations in PSCA can affect the risk of certain cancers.

Genome-wide association studies (GWAS) have revealed hundreds of genetic markers that could influence a person's risk of cancer and disease. One of these genes is PSCA, which encodes the prostate stem antigen of the prostate. The PSCA gene has been linked to several types of cancer including stomach cancer, as well as bladder cancer. Wu et al. discovered that Wu et al. found that the PSCA gene polymorphism rs2294008C to T was associated with bladder and esophageal cancer.

PSCA is overexpressed in certain types of cancer including prostate and bladder. One PSCA polymorphism, rs2294008 T to C, inhibits transcriptional activity in an upstream segment of the gene. The reason for this is not yet understood. It doesn't matter how polymorphism affects someone's susceptibility for certain types of cancer. It's a good idea to take a test to rule out risk factors for prostate cancer and other cancers.

Two additional PSCA polymorphisms were also identified as susceptibility genes in the study. One of these polymorphisms was found in the PSCA gene PSCA that conferred susceptibility to NGCA over GCA subtypes. This polymorphism can be found in a wide range of human tissues and was found to increase susceptibility to NGCA but not to the GCA subtype.

Over the past 10 years the field of preventive oncology has made huge strides. Two distinct syndromes have been identified that account for a significant portion of predisposition to the disease, and they have made a major difference in the lives families around the globe. Furthermore, the latest technological advancements have dramatically increased the capability to analyze the genetic variation within large populations. Several new associations have been discovered. The future research on these associations could provide new insights into the genetic causes of cancer susceptibility.

GWASs aren't yet conclusive, but they are useful in determining whether PSCA is involved in the development of various cancers. The study included more than 2,000 patients, as well as more than ten thousand control subjects. GWASs that have effect sizes of 1.5 to 2.0 fold are usually powered to detect the effect of common SNPs. However studies with effect size of 1.1-1.3 should be interpreted with caution. Lack of control cases and cases may suggest that genetic differences are insignificant and cannot be identified.