Periaxin Antibodies

Periaxin (Prx)

Scaffolding protein that functions as part of a dystroglycan complex in Schwann cells, and as part of EZR and AHNAK-containing complexes in eye lens fiber cells (PubMed:11430802, PubMed:21745462, PubMed:22764250). Required for the maintenance of the peripheral myelin sheath that's essential for normal transmission of nerve impulses and standard perception of sensory stimuli (PubMed:10839370).

Required for normal transport of MBP mRNA from the perinuclear to the paranodal regions (PubMed:15356632). Required for normal remyelination after nerve injury (PubMed:10839370).

Gene Information

Mouse
Gene Name:	Prx
Uniprot:	O55103
Entrez:	19153

Family

Belongs to:
periaxin family

Alternative Names

CMT4F; PRX

Molecular Weight

Mass (kDA):
147.688 kDA

Genomic Context

Mouse
Location:	7 A3|7 15.91 cM
Sequence:	7;

Tissue Specificity

Detected in myelinating Schwann cells in intramuscular nerves in triangularis sterni (PubMed:18205176). Detected in sciatic nerve (PubMed:11430802). Detected in eye lens fiber cells (PubMed:21745462). Isoform 1 is detected in myelinating Schwann cells in sciatic nerve (PubMed:9488714, PubMed:10671475, PubMed:10839370). Isoform 2 is detected in myelinating Schwann cells in sciatic nerve (at protein level) (PubMed:9488714, PubMed:10839370). Detected in sciatic nerve (PubMed:9488714, PubMed:10839370).

Diseases

• Malignant Neoplasms
• Neoplasms
• Charcot-marie-tooth Disease
• Carcinoma
• Dejerine-sottas Disease (disorder)
• Lung Neoplasms
• Inflammation
• Malignant Neoplasm Of Lung
• Nervousness
• Hereditary Motor And Sensory Neuropathies
• Neurodegenerative Disorders
• Stresses, Oxidative

• Intestinal Schistosomiasis
• Malaria
• Demyelination
• Demyelinating Diseases
• Parkinson Disease
• Cell Invasion
• Leukemia

Pathways

• Cell Death
• Pathogenesis
• Cell Proliferation
• Localization
• Photosynthesis
• Regeneration
• Secretion
• Rna Interference
• Response To Oxidative Stress
• Transport
• Aging
• Cell Cycle
• Cell Growth

• Electron Transport
• Senescence
• Gene Silencing
• Myelination
• Cellular Response To Oxidative Stress
• Proteolysis
• Drug Resistance

PTMs

• Oxidation
• Reduction
• Phosphorylation
• Cleavage
• Glutathionylation
• Acetylation
• Deglycosylation
• Deglutathionylation
• Ubiquitination

• Carboxylation
• Nitrosylation
• Phosphorothioation
• Amidation
• Dephosphorylation
• Biotinylation
• Nitration
• Glycosylation
• Myristoylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Prx

Boster Bio - Best Uses Of The PRX Marker

If you're shopping for an antibody, you've probably encountered the LF-PA0091 or the LF-PA2049. But what do these marks actually mean? Let's look at them and find out. What are their best uses. And why should you use them? Below, you'll find some facts to help you choose. You can even check out Boster's reviews and read what people are saying about their products.

LF-PA0091

The Boster Bio AntiPRX Picoband is a great option if you're in search of an ELISA Kit. The reagent binds PRX proteins and reacts with human, mouse, and rat samples. The price of the product is dependent on the length of the immunogen. This kit is suitable for testing specific proteins, species, and applications.

LF-PA2049

When you examine the features of Boster Bio the product, you'll see a high level of sensibility. Boster provides a range of antibodies that have high specificity and affinity. The company also validates its antibodies on multiple platforms, including Western Blotting, Immunohistochemistry, and ELISA. Using the Boster PRX Marker, you'll find the perfect match for your research.

The PRX gene encodes Periaxin, a protein that is involved in the maintenance of myelin in the peripheral nerve. It is composed of two PDZ domains: DlgA and ZO1. It is well-known that the gene is composed of two splice variants that are alternative, each encoding a different type of protein isoform. Charcot-MarieTooth Neuropathy is a disorder that affects the peripheral nerve system, and causes mutations to the PRX gene.