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Prrt2 Antibodies
AND Prrt2 ELISA kits, Prrt2 Proteins
Many biological assays use antibodies to detect Prrt2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Prrt2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Prrt2 antibodies...
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Prrt2 Overview
Facts about Proline-rich transmembrane protein 2.
Proline-rich transmembrane protein 2 (Prrt2)
As a part of the outer core of AMPAR complicated, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important part in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing (PubMed:27052163).
In the cerebellum, may inhibit SNARE complex formation and downregulate short-term facilitation (PubMed:29056747). .
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Prrt2 |
| Uniprot: | E9PUL5 |
| Entrez: | 69017 |
Family
| Belongs to: |
|---|
| CD225/Dispanin family |
Alternative Names
DKFZp547J199; FLJ25513; IFITMD1; interferon induced transmembrane protein domain containing 1; proline-rich transmembrane protein 2
Molecular Weight
Mass (kDA):
35.924 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 7|7 F3 |
| Sequence: | 7; |
Tissue Specificity
Neuron-specific expression throughout the brain, with the highest levels in the cerebellum, basal ganglia, hippocampus, substantia nigra, and neocortex (at protein level) (PubMed:22101681, PubMed:22243967, PubMed:22832103, PubMed:22632720, PubMed:25915028, PubMed:27052163, PubMed:27172900, PubMed:28007585, PubMed:29056747). Highly expressed also in spinal cord (at protein level) (PubMed:22101681, PubMed:22832103). Detected at very low levels in the heart, lung, kidney and skin (PubMed:22101681).
Diseases
- Dyskinetic Syndrome
- Convulsions
- Choreoathetosis
- Movement Disorders
- Chorea
- Dystonia Disorders
- Epilepsy
- Benign Neonatal Epilepsy
- Dyskinesia, Paroxysmal
- Involuntary Movements
- Paroxysmal Choreoathetosis
Pathways
- Pathogenesis
- Localization
- Vesicle Docking
- Exocytosis
PTMs
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Prrt2
bosterbio.com/bosterbio-gene-info-cards/Prrt2
References
PMID: 22101681 by Chen W.J., et al. Exome sequencing identifies truncating mutations in PRRT2 that cause paroxysmal kinesigenic dyskinesia.
PMID: 22243967 by Heron S.E., et al. PRRT2 mutations cause benign familial infantile epilepsy and infantile convulsions with choreoathetosis syndrome.