Pre-mRNA-processing-splicing factor 8 (PRPF8)

Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of this U4/U6-U5 tri-snRNP complicated.

Functions as scaffold that rankings spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site.