PRKCD Antibodies

Protein kinase C delta type (PRKCD)

Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by working as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor- initiated cell death, is involved in tumor suppression in addition to survival of many cancers, is needed for oxygen radical generation by NADPH oxidase and acts as negative or positive regulator in platelet functional responses. Negatively regulates B cell proliferation and also has a significant function in self- antigen induced B cell tolerance induction.

Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to activate BCLAF1-mediated p53/TP53 gene transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA from the nucleus, inducing the phosphorylation of p53/TP53.

Gene Information

Human
Gene Name:	PRKCD
Uniprot:	Q05655
Entrez:	5580

Family

Belongs to:
protein kinase superfamily

Alternative Names

EC 2.7.11; EC 2.7.11.13; MAY1; MGC49908; nPKC-delta; PKC delta; PKCD; PKCy; PRKCD; protein kinase C delta type; protein kinase C delta VIII; protein kinase C, delta

Molecular Weight

Mass (kDA):
77.505 kDA

Genomic Context

Human
Location:	3p21.1
Sequence:	3; NC_000003.12 (53161209..53192717)

Subcellular Localizations

Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Cell membrane; Peripheral membrane protein.

Diseases

• Neoplasms
• Malignant Neoplasms
• Ischemia
• Tissue Adhesions
• Diabetes Mellitus
• Leukemia
• Carcinoma
• Myocardial Ischemia
• Inflammation
• Hypertrophy
• Malignant Neoplasm Of Breast
• Infarction
• Mammary Neoplasms

• Neoplasm Metastasis
• Myocardial Reperfusion Injury
• Cell Transformation, Neoplastic
• Hypoxia
• Myocardial Infarction
• Growth Arrest
• Insulin Resistance

Interacting Proteins

• CARD11
• DIABLO
• FYN
• GAP43
• NCF2

• TOP2A
• TP53
• TP63

Pathways

• Cell Death
• Localization
• Cell Growth
• Cell Proliferation
• Secretion
• Cell Cycle
• Induction Of Apoptosis
• Pathogenesis
• Proteolysis
• Transport
• Cell Migration
• Cell Adhesion
• Cell Cycle Arrest

• Cell Differentiation
• Sensitization
• Phagocytosis
• Cell Activation
• Cell Motility
• Keratinocyte Differentiation
• Hyperphosphorylation

PTMs

• Phosphorylation
• Cleavage
• Dephosphorylation
• Myristoylation
• Oxidation
• Ubiquitination
• Acylation
• Cysteinylation

• Biotinylation
• Acetylation
• Sumoylation
• Formylation
• Phosphorothioation
• Prenylation
• Nitration
• Farnesylation

• Geranylgeranylation

Research Areas

• Phospho-Specific
• Protein Kinase
• Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PRKCD

Best Uses of the PRKCD Marker

The PRKCD marker can be used in a variety of ways. These markers can be used to determine if a person requires mechanical ventilation. You can also use this to determine whether the patient has conditions that can be treated using medications. Here are some of the most useful applications for the PRKCD marker. Continue reading to find more. The best uses of this marker are:

NTRK2 receptor

The PRKCD marker NTRK2 is an antibody rabbit polyclonal that recognizes NTRK2 and Twist in biological samples. It is diluted to 1:1000 and tested on human brain tissue. It is also used to detect BDNF an important neurotrophic cytokine. It has been approved for use in research and development for clinical use.

NTRK2 has been linked to a range of mental disorders and genetic predisposition. The gene has been associated with white matter in the brain, which makes it a suitable candidate for psychopathology. Although further studies are needed to study the effects of NTRK2 on emotion processing this marker has already shown promising results. It is also used to predict the likelihood of developing certain psychiatric disorders.

Neurotrophins are well-known for their positive and negative effects on neuronal biology. Many receptors, including NTRK, TrkA, and TrkB are involved in neurotrophin signaling. It is difficult to understand the way these receptors communicate with each other as they each have distinct and mutually exclusive signaling functions. The PRKCD marker for the NTRK2 receptor plays a significant role in the identification and diagnosis of many disorders and diseases.

The PRKCD ELISA Kit is a very useful diagnostic instrument. It can detect the NTRK2 protein in body fluids. This ELISA kit has excellent reproducibility and minimal cross-reactivity to analogs. The PRKCD kit can be used for both clinical and research purposes. In vitro detection is possible, the PRKCD marker for NTRK2 receptor can be utilized as a sandwich ELISA test kit. It can detect NTRK2 concentrations in samples and is stored at between two and eight degrees C.

COVID-19

The best uses of the PRKCD marker in COVID-19 were based on data from a federated electronic health record database that has data on 81 million patients across sixty-two health care organizations. The database has information on women's health. It identified two COVID-19 cohorts: one with an established diagnosis, and the other without a known reason. These three cohorts were discovered by COVID-19 positive women. They did not include women suffering from other respiratory or neurologic disorders.

NCR1 receptor

Boster's most popular high affinity antibodies include the PRKCD marker. The antibodies are endorsed by a variety of research groups and have an impressive citation record in top scientific journals. They are also made by hand, which guarantees highest quality and efficiency. Additionally, the company provides customized services that meet your exact requirements. Contact us today to learn more! We're happy to assist you with your research!

The Boster Bio test is a diagnostic and prognostic instrument that is of exceptional predictive and diagnostic value. While it is a reliable gauge of antibiotic response and response, it should be used in conjunction with other diagnostic tests recommended by healthcare experts. Independent raters have categorize the patients into two groups. The test has a Light's Kappa value of 0.837 which makes it a highly effective diagnostic instrument.

The boster bio antibody is an IL-6 Cytokine. It is used to diagnose the presence of disease and aid researchers in determining whether cancer cells are prone to inflammation. In order to methylate IL-6, it is a process that requires an RNA-guide. A methylated RNA molecule will be able to interact more with cancerous cells and trigger an immune response.

The cytokine IL6

The IL6 Cytokine is distinguished by its proinflammatory properties. It is produced by a variety of types of immune cells as well as nonimmune cells. Its primary functions are bone maintenance in addition to inflammation, immune function, and immune function. It is also used in the analysis of cardiovascular disease, diabetes and cancer. Its function in the immune system is a subject of great debate and is not understood in any way.

The COVID-CSS is currently not a standard diagnostic tool however it could be used to detect an overactive immune system in various circumstances. Patients suffering from COVID-CSS display an elevated level of IL-6 as well as a spectrum of end organ damage. Although IL-6 levels aren't widely available in clinical labs however, it is fairly inexpensive and easy to acquire.

The IL-6 a-helical is a pleiotropic cytokine , which is involved in the immune response and inflammation. It also plays a role in bone metabolism and cancer progression. Its mature protein is 183 amino acids long and shares 39% sequence similarity to mice and rat IL-6. It is possible to see it in a variety of forms, some of which have antagonistic properties.

Recent research has shown that the IL-6 cytokine is an important inflammatory mediator. The IL-6 cytokine is an agent in autoimmune inflammation such as rheumatoid arthritis and inflammatory digestive disorders is a therapeutic target. The anti-inflammatory properties of IL-6 cytokine are also evident. Its anti-inflammatory properties have been demonstrated in different types of tumours, evidence of the importance of IL-6's role in cancer biology.

The IL-6 protein plays a vital role in intercellular communication within cancer cell niches. It also has profound effects on the system. Failure of IL-6 can lead to grave physical and mental consequences for the patient. Inflammation is a hallmark of malignancies and acute infectious diseases. Its levels are related to respiratory failure and with the requirement for oxygen. This could explain the correlations between the levels of IL-6 and respiratory dysfunction.