Protein kinase C alpha type (PRKCA)

Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating goals like RAF1, BCL2, CSPG4, TNNT2/CTNT, or triggering signaling cascade between MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle.

Can encourage cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can activate a cell cycle arrest program that's related to the accumulation of the hyper-phosphorylated growth-suppressive type of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B.