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- Table of Contents
Facts about 5'-AMP-activated protein kinase subunit gamma-3.
AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin.
Human | |
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Gene Name: | PRKAG3 |
Uniprot: | Q9UGI9 |
Entrez: | 53632 |
Belongs to: |
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5'-AMP-activated protein kinase gamma subunit family |
5'-AMP-activated protein kinase subunit gamma-3; AMPK gamma 3; AMPK gamma-3 chain; AMPK gamma3; AMPK subunit gamma-3; AMPKG3; AMPKG3,5'-AMP-activated protein kinase, gamma-3 subunit; PRKAG3; protein kinase, AMP-activated, gamma 3 non-catalytic subunit
Mass (kDA):
54.258 kDA
Human | |
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Location: | 2q35 |
Sequence: | 2; NC_000002.12 (218819949..218831803, complement) |
Skeletal muscle, with weak expression in heart and pancreas.
PMID: 10698692 by Cheung P.C.F., et al. Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding.
PMID: 10818001 by Milan D., et al. A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscle.