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PRKAB1 Antibodies
AND PRKAB1 ELISA kits, PRKAB1 Proteins
Many biological assays use antibodies to detect PRKAB1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PRKAB1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PRKAB1 antibodies...
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PRKAB1 Infographic by Boster Bio
All PRKAB1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, WB
$370
Cat # M03741
100 μl
Cat # M03741
100 μl
Human, Mouse, Rat
ELISA
$480
Cat # EKC1026
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1026
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2018
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2018
1 kit, containing two 96-well plates and all necessary reagents
Human, Monkey, Mouse, Rat
IP, IHC, ICC, WB
$482
Cat # M03741-1
100ul
Cat # M03741-1
100ul
Human, Mouse, Rat
ELISA, IHC, WB
$380
Cat # A03741S182
100ul
Cat # A03741S182
100ul
PRKAB1 Overview
Facts about 5'-AMP-activated protein kinase subunit beta-1.
5'-AMP-activated protein kinase subunit beta-1 (PRKAB1)
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming procedures: inhibits protein, carbohydrate and lipid biosynthesis, in addition to cell growth and proliferation.
AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; likely by indirectly activating myosin.
Gene Information
| Human | |
|---|---|
| Gene Name: | PRKAB1 |
| Uniprot: | Q9Y478 |
| Entrez: | 5564 |
Family
| Belongs to: |
|---|
| 5'-AMP-activated protein kinase beta subunit family |
Alternative Names
5'-AMP-activated protein kinase beta-1 subunit; AMP-activated protein kinase beta subunit; AMPK beta -1 chain; AMPK beta 1; AMPK beta 1,5'-AMP-activated protein kinase subunit beta-1; AMPK subunit beta-1; AMPK; AMPKb; HAMPKb; MGC17785; PRKAB1; protein kinase, AMP-activated, beta 1 non-catalytic subunit; protein kinase, AMP-activated, noncatalytic, beta-1
Molecular Weight
Mass (kDA):
30.382 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q24.23 |
| Sequence: | 12; NC_000012.12 (119667864..119681624) |
Diseases
- Diabetes Mellitus
- Diabetes Mellitus, Non-insulin-dependent
- Obesity
- Insulin Resistance
- Insulin Sensitivity
- Malignant Neoplasms
- Malignant Neoplasm Of Breast
- Hypoxia
- Carcinoma
- Neoplasms
- Hyperinsulinism
- Hypertrophy
Interacting Proteins
- Cidea
- GRB2
- PRKAA1
- PRKAA2
- PRKAG1
- ULK1
Pathways
- Energy Homeostasis
- Fatty Acid Oxidation
- Localization
- Cellular Localization
- Cell Growth
- Pathogenesis
- Cell Killing
- Dna Methylation
- Oocyte Maturation
- Cell Cycle Arrest
- Senescence
PTMs
- Phosphorylation
- Oxidation
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PRKAB1
bosterbio.com/bosterbio-gene-info-cards/PRKAB1
References
PMID: 9224708 by Stapleton D., et al. AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location.
PMID: 17028174 by Baba M., et al. Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling.