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PRKACA Antibodies
AND PRKACA ELISA kits, PRKACA Proteins
Many biological assays use antibodies to detect PRKACA, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PRKACA in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PRKACA antibodies...
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PRKACA Infographic by Boster Bio
All PRKACA Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IF, IHC-P, ICC, WB
$399
Cat # A00653
100μl
Cat # A00653
100μl
Human, Mouse, Rat
ELISA
$480
Cat # EKC1682
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1682
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2107
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2107
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
IHC, WB
$482
Cat # A00653T197
100ul
Cat # A00653T197
100ul
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A00653T198
100ul
Cat # A00653T198
100ul
Human, Mouse, Rat
ELISA, IHC
$380
Cat # A00653S338
100ul
Cat # A00653S338
100ul
PRKACA Overview
Facts about cAMP-dependent protein kinase catalytic subunit alpha.
cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)
Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis.
RORA is triggered by phosphorylation. Required for sugar - mediated adipogenic differentiation growth and osteogenic differentiation inhibition from osteoblasts.
Gene Information
| Human | |
|---|---|
| Gene Name: | PRKACA |
| Uniprot: | P17612 |
| Entrez: | 5566 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
PKA C alpha/beta; PRKACA/B
Molecular Weight
Mass (kDA):
40.59 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.12 |
| Sequence: | 19; NC_000019.10 (14091688..14117762, complement) |
Tissue Specificity
Isoform 1 is ubiquitous. Isoform 2 is sperm- specific and is enriched in pachytene spermatocytes but is not detected in round spermatids.
Subcellular Localizations
Cytoplasm. Cell membrane. Nucleus. Mitochondrion. Membrane; Lipid-anchor. Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm. Distributed throughout the cytoplasm in meiotically incompetent oocytes. Associated to mitochondrion as meiotic competence is acquired. Aggregates around the germinal vesicles (GV) at the immature GV stage oocytes (By similarity). Colocalizes with HSF1 in nuclear stress bodies (nSBs) upon heat shock (PubMed:21085490).; [Isoform 2]: Cell projection, cilium, flagellum. Cytoplasmic vesicle, secretory vesicle, acro
Diseases
- Malignant Neoplasms
- Neoplasms
- Cell Transformation, Neoplastic
- Carcinoma
- Stomach Neoplasms
- Malignant Neoplasm Of Breast
- Polyps
- Malignant Tumor Of Colon
- Glioma
- Lung Diseases
- Myxoid Degeneration
- Melancholic Depression
Interacting Proteins
- AICDA
- AKIP1
- ALOX5
- APOBEC3G
- Gnao1
- GSK3B
- LRRK2
- PRKAR1A
- PRKAR1B
- PRKAR2B
Pathways
- Pathogenesis
- Localization
- Methylation
- Hyperphosphorylation
- Reverse Transcription
- Translation
- Tube Formation
- Fibroblast Proliferation
- Chromatin Organization
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PRKACA
bosterbio.com/bosterbio-gene-info-cards/PRKACA
References
PMID: 2843813 by Maldonado F., et al. A cDNA clone encoding human cAMP-dependent protein kinase catalytic subunit C alpha.
PMID: 10906071 by Reinton N., et al. A novel isoform of human cyclic 3',5'-adenosine monophosphate- dependent protein kinase, c alpha-s, localizes to sperm midpiece.