PRDM5 Antibodies

AND PRDM5 ELISA kits, PRDM5 Proteins

Many biological assays use antibodies to detect PRDM5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PRDM5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PRDM5 antibodies...

We validate the specificity of these antibodies to PRDM5 by testing them on tissues known to express PRDM5 positively and negatively. Browse below to find the PRDM5 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PRDM5 Infographic by Boster Bio

All PRDM5 Products

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Product

Figures

Specificity

Applications

Price

Anti-PRDM5 Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A06736-1
100 μg/vial

PRDM5 (NM_018699) Human Over-expression Lysate

Human

$960
Cat # LS011107
100 µg

PRDM5 Overview

Facts about PR domain zinc finger protein 5.

PRDM5 3D structure. Source: alphafold

PR domain zinc finger protein 5 (PRDM5)

Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1.

Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue elements, such as HAPLN1, and molecules regulating cell migration and adhesion, such as EDIL3 and TGFB2.

Gene Information

Human
Gene Name:	PRDM5
Uniprot:	Q9NQX1
Entrez:	11107

Family

Belongs to:

class V-like SAM-binding methyltransferase superfamily

Alternative Names

PFM2PR domain-containing protein 5; PR domain containing 5; PR domain zinc finger protein 5

Molecular Weight

Mass (kDA):
73.09 kDA

Genomic Context


Human

Location:	4q27
Sequence:	4; NC_000004.12 (120684906..120922866, complement)

Tissue Specificity

Widely expressed with highest levels in colon and ovary. Tends to be silenced in breast, colorectal, gastric and liver cancer tissues.

Subcellular Localizations

Nucleus.

Diseases

Neoplasms
Malignant Neoplasms
Carcinogenesis
Ehlers-danlos Syndrome 6b
Ehlers-danlos Syndrome
Carcinoma
Liver Carcinoma
Corneal Diseases
Stomach Neoplasms
Malignant Paraganglionic Neoplasm
Malignant Neoplasm Of Stomach

Liver Neoplasms
Joint Laxity
Anophthalmos
Uterine Cervical Neoplasm
Hepatitis B
Malignant Neoplasm Of Liver

Interacting Proteins

EHMT2
GFI1
HDAC1

Pathways

Methylation
Dna Methylation
Cell Differentiation
Cell Growth
Enucleation
Gastrulation
Cell Proliferation
Organ Maturation
Histone Modification

Ossification
Pathogenesis
Demethylation

PTMs

Methylation

Demethylation

Research Areas

Chromatin Research
Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PRDM5

References

PMID: 15077163 by Deng Q., et al. PRDM5 is silenced in human cancers and has growth suppressive activities.

PMID: 17699856 by Watanabe Y., et al. PRDM5 identified as a target of epigenetic silencing in colorectal and gastric cancer.