PRAME Antibodies

AND PRAME ELISA kits, PRAME Proteins

Many biological assays use antibodies to detect PRAME, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PRAME in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PRAME antibodies...

We validate the specificity of these antibodies to PRAME by testing them on tissues known to express PRAME positively and negatively. Browse below to find the PRAME antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PRAME Infographic by Boster Bio

All PRAME Products

Product

Figures

Specificity

Applications

Price

Anti-PRAME Picoband™ Antibody

Human

ELISA, WB

$370
Cat # A06628-2
100 μg/vial

Anti-PRAME Antibody

Human, Mouse, Rat

$405
Cat # A06628
100ul

Anti-MAPE Antibody (C-term)

Human

Flow Cytometry, IHC-P, WB

$298
Cat # A06628-1
80 µl

PRAME (NM_006115) Human Over-expression Lysate

Human

$628
Cat # LS023532
100 µg

PRAME Overview

Facts about Melanoma antigen preferentially expressed in tumors.

PRAME 3D structure. Source: alphafold

Melanoma antigen preferentially expressed in tumors (PRAME)

Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.

Gene Information

Human
Gene Name:	PRAME
Uniprot:	P78395
Entrez:	23532

Family

Belongs to:

PRAME family

Alternative Names

cancer/testis antigen 130; MAPEOIP4CT130; melanoma antigen preferentially expressed in tumors; OIP-4; Opa-interacting protein 4; Opa-interacting protein OIP4; preferentially expressed antigen in melanoma; Preferentially expressed antigen of melanoma

Molecular Weight

Mass (kDA):
57.89 kDA

Genomic Context


Human

Location:	22q11.22
Sequence:	22; NC_000022.11 (22547696..22559361, complement)

Tissue Specificity

Expressed in testis. Detected in samples of kidney, brain and skin.

Subcellular Localizations

Nucleus. Cell membrane.

Diseases

Neoplasms
Leukemia
Malignant Neoplasms
Melanoma
Myeloid Leukemia
Leukemia, Myelocytic, Acute
Neoplasm, Residual
Myeloid Leukemia, Chronic
Carcinoma
Malignant Paraganglionic Neoplasm
Hematologic Neoplasms
Acute Lymphocytic Leukemia
Lymphoma

Neoplasm Metastasis
Acute Leukemia
Lymphoid Leukemia
Chronic Lymphocytic Leukemia
Aortic Aneurysm, Thoracic
Skin Neoplasms
Blast Phase

Pathways

Immune Response
Cell Cycle
Methylation
Cell Cycle Arrest
Dna Methylation
Pathogenesis
Reverse Transcription
Cell Proliferation
Melanocyte Differentiation
Spermatogenesis
Rna Interference
Cell Adhesion
Transposition

Stem Cell Differentiation
Protein Unfolding
Chromosome Segregation
Cell Differentiation
Detection Of Tumor Cell
Phototransduction
Oogenesis

PTMs

Methylation

Demethylation

Myristoylation

Research Areas

Cancer

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PRAME

References

PMID: 9047241 by Ikeda H., et al. Characterization of an antigen that is recognized on a melanoma showing partial HLA loss by CTL expressing an NK inhibitory receptor.

PMID: 9466265 by Williams J.M., et al. Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth.