PRAM1 Antibodies

AND PRAM1 ELISA kits, PRAM1 Proteins

Many biological assays use antibodies to detect PRAM1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PRAM1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PRAM1 antibodies...

We validate the specificity of these antibodies to PRAM1 by testing them on tissues known to express PRAM1 positively and negatively. Browse below to find the PRAM1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PRAM1 Infographic by Boster Bio

All PRAM1 Products

Product

Figures

Specificity

Applications

Price

PRAM1 (NM_032152) Human Recombinant Protein

$1249
Cat # PROTQ96QH2
20 µg

PRAM1 (NM_032152) Human Over-expression Lysate

Human

$628
Cat # LS084106
100 µg

Anti-PRAM1 Antibody Picoband™

Human

ELISA, Flow Cytometry, WB

$370
Cat # A10037-2
100 µg/vial

PRAM1 Overview

Facts about PML-RARA-regulated adapter molecule 1.

PRAM1 3D structure. Source: alphafold

PML-RARA-regulated adapter molecule 1 (PRAM1)

May be involved in myeloid differentiation. May be involved in integrin signaling in neutrophils.

Binds to PtdIns(4)P. .

Gene Information

Human
Gene Name:	PRAM1
Uniprot:	Q96QH2
Entrez:	84106

Family

Belongs to:

No superfamily

Alternative Names

MGC39864; PML-RAR; PML-RARA regulated adaptor molecule 1; PML-RARA target gene encoding an Adaptor Molecule-1; PML-RARA-regulated adapter molecule 1; PRAM; PRAM-1

Molecular Weight

Mass (kDA):
73.969 kDA

Genomic Context


Human

Location:	19p13.2
Sequence:	19; NC_000019.10 (8490055..8502640, complement)

Tissue Specificity

Expressed in peripheral blood leukocytes and bone marrow. Expressed in monocytes, and to a lesser extent in granulocytes and lymphocytes. Not expressed in non hematopoietic tissues except in lung.

Diseases

Leukemia
Leukemia, Myelocytic, Acute
Myeloid Leukemia
Acute Promyelocytic Leukemia
Neoplasms
Cytogenetic Abnormality
Acute Myelomonocytic Leukemia
Hematopoietic Neoplasms
Neoplasm, Residual
Cardiovascular Diseases
Malignant Neoplasms
Chimera Disorder

Cell Invasion
Cell Transformation, Neoplastic
African Trypanosomiasis
Malignant Paraganglionic Neoplasm
Tissue Adhesions
Acute Lymphocytic Leukemia
Nephroblastoma

Interacting Proteins

ABI2
CCDC57
FXR2
KRT40
RNF32

SKAP1
TRIM27

Pathways

Pathogenesis
Neutrophil Differentiation
Lipid Binding

PTMs

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PRAM1

References

PMID: 11301322 by Moog-Lutz C., et al. PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cells.

PMID: 15637062 by Denis F.M., et al. PRAM-1 potentiates arsenic trioxide-induced JNK activation.