Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (PPP3CA)

Calcium-dependent, calmodulin-stimulated protein phosphatase that plays a vital role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:15671020, PubMed:18838687, PubMed:19154138, PubMed:23468591). Many of the substrates contain a PxIxIT motif or a LxVP motif (PubMed:17498738, PubMed:17502104, PubMed:23468591, PubMed:27974827, PubMed:22343722).

In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (PubMed:15671020). In response to increased Ca(2+) levels after mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation into the mitochondrion (PubMed:18838687).