PPP3CA Antibodies

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (PPP3CA)

Calcium-dependent, calmodulin-stimulated protein phosphatase that plays a vital role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:15671020, PubMed:18838687, PubMed:19154138, PubMed:23468591). Many of the substrates contain a PxIxIT motif or a LxVP motif (PubMed:17498738, PubMed:17502104, PubMed:23468591, PubMed:27974827, PubMed:22343722).

In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (PubMed:15671020). In response to increased Ca(2+) levels after mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation into the mitochondrion (PubMed:18838687).

Gene Information

Human
Gene Name:	PPP3CA
Uniprot:	Q08209
Entrez:	5530

Family

Belongs to:
PPP phosphatase family

Alternative Names

calcineurin A alpha; Calcineurin A; Calmodulin-dependent calcineurin A subunit alpha isoform; CALN; CALNA; CALNAcatalytic subunit, alpha isoform; CAM-PRP catalytic subunit; CNA; CNA1; CNA1CALNA1; EC 3.1.3.16; PP2B; PP3CA; PPP2B; PPP2BCCN1; PPP3CA; protein phosphatase 2B, catalytic subunit, alpha isoform; protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform(calcineurin A alpha); protein phosphatase 3, catalytic subunit, alpha isozyme; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

Molecular Weight

Mass (kDA):
58.688 kDA

Genomic Context

Human
Location:	4q24
Sequence:	4; NC_000004.12 (101023418..101348295, complement)

Subcellular Localizations

Cytoplasm. Cell membrane; Peripheral membrane protein. Cell membrane, sarcolemma. Cytoplasm, myofibril, sarcomere, Z line. Cell projection, dendritic spine. Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle (By similarity). Recruited to the cell membrane by scaffold protein AKAP5 following L-type Ca(2+)-channel activation (PubMed:22343722).

Diseases

• Malignant Neoplasms
• Neoplasms
• Alzheimer's Disease
• Carcinoma, Transitional Cell
• Reperfusion Injury
• Neoplasm Metastasis
• Malignant Neoplasm Of Breast
• Thymoma
• Cardiac Hypertrophy
• Bone Neoplasms
• Premature Aging Syndrome
• Malignant Neoplasm Of Lung
• Malignant Neoplasm Of Urinary Bladder

• Carcinoma
• Myopathy
• Carcinoma In Situ
• Cardiovascular Diseases
• Edema
• Tumor Angiogenesis
• Neoplasms, Hormone-dependent

Interacting Proteins

• AKAP5
• Cacng8
• GRB2
• NFATC1
• NFATC2

• PPP3R1
• USP14
• UTRN

Pathways

• Cell Proliferation
• Protein Phosphorylation
• Transport
• Hyperphosphorylation
• Skeletal Muscle Adaptation
• Cell Migration
• Aging
• Oxidative Phosphorylation
• Muscle Adaptation
• Biosynthetic Process
• Localization
• Spermatogenesis
• Cell Death

• Cell Cycle
• Bone Remodeling
• Angiogenesis
• Fatty Acid Oxidation
• Glucose Transport
• Bone Resorption
• Secretion

PTMs

• Phosphorylation

• Dephosphorylation

Research Areas

• Adaptive Immunity
• Immunology
• Protein Phosphatase
• Wnt Signaling Pathway

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PPP3CA

Boster Bio - Best Uses Of The PPP3CA Marker

Boster Bio Anti Calcineurin/PPP3CA Marker might be the right choice, no matter if you are a beginner or an expert. Luckily, there's no need to worry - our review will help you make the best choice. Read on to discover the benefits of this marker, and how you can use it for your research.

Boster Bio: Anti-Calcineurin A/PPP3CA Marker

The PPP3CA Marker is a phosphoprotein found in the nuclei of myocytes. It is induced and activated by IGF1 as well as calcineurin. It associates with calcineurin, a specific dephosphorylated NFATC1 form. Several biochemical assays use this marker to identify diseases affecting muscle tissue.

Boster Bio: Anti-Calcineurin A

The PPP3CA Marker is a gene encoding a protein that is expressed in E.coli. This gene is involved in the production of myocytes. It has a sequence domain containing one to five11 amin acids. The gene is expressed within the muscle. It is induced by activated calcineurin, IGF1, and other stimuli. The protein can store at -20 to 80° Celsius and can be used for up to one year in biological samples. The protein is highly applicable to researchers working in various fields.