Ppp1r1b Antibodies

Protein phosphatase 1 regulatory subunit 1B (Ppp1r1b)

Inhibitor of protein-phosphatase 1. .

Gene Information

Mouse
Gene Name:	Ppp1r1b
Uniprot:	Q60829
Entrez:	19049

Family

Belongs to:
protein phosphatase inhibitor 1 family

Alternative Names

DARPP32; DARPP-32; PPP1R1B; protein phosphatase 1, regulatory (inhibitor) subunit 1B; regulatory (inhibitor) subunit 1B (dopamine and cAMPregulated phosphoprotein, DARPP-32)

Molecular Weight

Mass (kDA):
21.781 kDA

Genomic Context

Mouse
Location:	11|11 D
Sequence:	11;

Diseases

• Huntington Disease
• Schizophrenia
• Parkinson Disease
• Malignant Neoplasms
• Neurodegenerative Disorders
• Neoplasms
• Mental Disorders
• Dyskinetic Syndrome
• Atrophy
• Secondary Parkinson Disease
• Stomach Neoplasms
• Dyskinesia, Drug-induced

• Bipolar Disorder
• Adenocarcinoma
• Malignant Neoplasm Of Stomach
• Malnutrition
• Substance-related Disorders
• Attention Deficit Hyperactivity Disorder
• Movement Disorders

Pathways

• Pathogenesis
• Sensitization
• Innervation
• Transport
• Cognition
• Neuroprotection
• Cell Death
• Locomotion
• Protein Phosphorylation
• Hyperphosphorylation
• Neurogenesis
• Localization
• Gene Silencing

• Aging
• Regulation Of Gene Expression
• Nuclear Export
• Translation
• Long-term Memory
• Chromatin Remodeling
• Regulation Of Phosphorylation

PTMs

• Phosphorylation
• Dephosphorylation
• Acetylation

• Deacetylation
• Cleavage
• Palmitoylation

Research Areas

• Breast Cancer
• Neuronal Cell Markers
• Neuroscience
• Neurotransmission
• Phospho-Specific

• Protein Phosphatase
• Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Ppp1r1b

Boster Bio: Best Uses Of The PPP1R1B Marker

Boster scientists can submit their research results to the Boster laboratory for specific samples, species, applications and other purposes. They are able to submit their research results as well as receive credit for their work. These credits can be used all over the world. The benefits aren't only available to researchers from one country; they are accessible to all researchers. For more information about the ways this product can help you in your research, read on.

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PPP1R1B is a major regulator of neuronal activity. Brain function is closely linked with the levels of expression of PPP1R1B. Although the exact mechanism is still unclear, genetic labeling can be utilized to identify rare cells or clones. For instance, an inverted transgenic clone containing Cre-mediated Recombination (CMR) drives the expression of GFP-KASH. The gene was expressed in primary cortical neurons co-infected with pAAV-EF1a-DIO-GFP-KASH-bGHpolyA-Cre-WPRE-bGHpolyA.

InVivo Biosystems Custom zebrafish/c. elegans genome edited models for PPP1R1B

InVivo Biosystems has over 40 years of experience in editing genes for zebrafish. In collaboration with the Center for Molecular Biology, the zebrafish genome editing system of PPP1R1B is being developed. The zebrafish genome editing system is a complete replica of the STXBP1 human gene. The human coding sequence has been inserted into the native locus of the C. the elegans ortholog gene. The humanized strain was found to have low activity while the knockout strain had moderate activity.

The genome editing model of zebrafish of PPP1R1B allows researchers to examine the effect of genetic deletion on encoded protein. Students conducted bioinformatics analysis after confirmation of the deletion with a nested Polymerase Chain Reaction. Students also conducted RNA interference against the corresponding gene to find out if the deletion had an equivalent effect on worms. Finally, students prepared scientific posters and evaluated the viability of using C. elegans as a model organism. The utility of the model organism is demonstrated by the posters and research findings of the students.

These models are ideal for studies that study gene-gene interactions within the context of biological problems. Through the study of multiple combinations of data from experiments The custom models developed for PPP1R1B can aid researchers to understand the complexities of biological problems. These models allow researchers to test and verify their theories about PPP1R1B.

ORMD lets users deposit gene expression data and manage their projects. Contributors can make their data either private or public. The datasets are searchable after they have been uploaded and can be downloaded in their raw format. The datasets are linked to ORMD via hyperlinks, which let users explore their proteomic and genomic data. ORMD is also a secure data repository for OR analysis of gene expression.