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- Table of Contents
Facts about Protein phosphatase 1 regulatory inhibitor subunit 16B.
Protects the endothelial barrier from lipopolysaccharide (LPS)- induced vascular leakage (By similarity). Involved in the regulation of endothelial cell filopodia extension (By similarity).
Human | |
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Gene Name: | PPP1R16B |
Uniprot: | Q96T49 |
Entrez: | 26051 |
Belongs to: |
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No superfamily |
ANKRD4TIMAPankyrin repeat domain protein 4; Ankyrin repeat domain-containing protein 4; CAAX box protein TIMAP; hTIMAP; KIAA0823TGF-beta-inhibited membrane-associated protein; protein phosphatase 1 regulatory inhibitor subunit 16B; protein phosphatase 1, regulatory (inhibitor) subunit 16B
Mass (kDA):
63.551 kDA
Human | |
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Location: | 20q11.23 |
Sequence: | 20; NC_000020.11 (38805694..38923024) |
Cell membrane. Cell membrane; Lipid-anchor. Nucleus. Cell projection. Colocalizes with RPSA/LAMR1 in the cell membrane (PubMed:16263087). Localizes to the perinuclear region (By similarity). Colocalizes with PTEN at the tip of EC projections (PubMed:25007873).
PMID: 12055102 by Cao W., et al. TIMAP, a novel CAAX box protein regulated by TGF-beta1 and expressed in endothelial cells.
PMID: 15491607 by Homma K., et al. Alternative splice variants encoding unstable protein domains exist in the human brain.