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Ppp1r15a Antibodies
AND Ppp1r15a ELISA kits, Ppp1r15a Proteins
Many biological assays use antibodies to detect Ppp1r15a, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Ppp1r15a in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Ppp1r15a antibodies...
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Ppp1r15a Infographic by Boster Bio
All Ppp1r15a Products
Product
Figures
Specificity
Applications
Price
Dog, Human, Monkey, Mouse, Rat
Flow Cytometry, IF, IHC, WB
$560
Cat # M02394
100 µl
Cat # M02394
100 µl
Mouse
ELISA, Flow Cytometry, WB
$370
Cat # A02394-4
100 μg/vial
Cat # A02394-4
100 μg/vial
Ppp1r15a Overview
Facts about Protein phosphatase 1 regulatory subunit 15A.
Protein phosphatase 1 regulatory subunit 15A (Ppp1r15a)
Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1.
May promote apoptosis by inducing TP53 phosphorylation on'Ser-15'. In the event of infection with vesicular stomatitis virus (VSV), impairs viral replication.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Ppp1r15a |
| Uniprot: | P17564 |
| Entrez: | 17872 |
Family
| Belongs to: |
|---|
| PPP1R15 family |
Alternative Names
GADD34Growth arrest and DNA damage-inducible protein GADD34; growth arrest and DNA-damage-inducible 34; Myeloid differentiation primary response protein MyD116 homolog; protein phosphatase 1 regulatory subunit 15A; protein phosphatase 1, regulatory (inhibitor) subunit 15A
Molecular Weight
Mass (kDA):
71.84 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 7|7 B3 |
| Sequence: | 7; |
Tissue Specificity
Expressed strongly in spleen and lung, moderately in thymus and muscle, and weakly in brain.
Diseases
- Growth Arrest
- Neoplasms
- Malignant Neoplasms
- Endoplasmic Reticulum Stress
- Physiological Stress
- Virus Diseases
- Leukemia
- Malignant Paraganglionic Neoplasm
- Ischemia
- Cell Transformation, Neoplastic
- Melanoma
- Tumor Angiogenesis
Pathways
- Translation
- Cell Death
- Dna Repair
- Cell Growth
- Viral Replication
- Cell Cycle
- Cell Differentiation
- Cell Proliferation
- Immune Response
- Localization
- Angiogenesis
- Programmed Cell Death
- Cell Cycle Arrest
PTMs
- Phosphorylation
- Dephosphorylation
Research Areas
- Apoptosis
- Lipid and Metabolism
- Unfolded Protein Response
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Ppp1r15a
bosterbio.com/bosterbio-gene-info-cards/Ppp1r15a
References
PMID: 2339071 by Lord K.A., et al. Sequence of MyD116 cDNA: a novel myeloid differentiation primary response gene induced by IL6.
PMID: 8139541 by Zhan Q., et al. The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth.