Protein phosphatase 1D Antibodies

AND PPM1D ELISA kits, Protein phosphatase 1D Proteins

Many biological assays use antibodies to detect Protein phosphatase 1D, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein phosphatase 1D in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein phosphatase 1D antibodies...

We validate the specificity of these antibodies to Protein phosphatase 1D by testing them on tissues known to express PPM1D positively and negatively. Browse below to find the PPM1D antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PPM1D Infographic by Boster Bio

All PPM1D Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-PPM1D/WIP1 Picoband® Antibody

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A01576-1
100 μg/vial

Anti-Protein phosphatase 1D PPM1D Antibody

Human, Mouse, Rat

ELISA, IF, IHC-P, WB

$449
Cat # A01576
0.1 mg

Human PPM1D Recombinant Protein

SDS-PAGE, Denatured

$250
Cat # PROTQ8NEA7
Starting from 10ug

Anti-PPM1D Mouse Monoclonal Antibody [Clone ID: OTI3E1]

Human, Mouse, Rat

$523
Cat # M01576
100 µl

PPM1D (NM_003620) Human Over-expression Lysate

Human

$628
Cat # LS008493
100 µg

PPM1D Overview

Facts about Protein phosphatase 1D.

PPM1D 3D structure. Source: alphafold

Protein phosphatase 1D (PPM1D)

Involved in the negative regulation of p53 expression (PubMed:23242139). Required for the aid of p53-dependent checkpoint mediated cell cycle arrest.

Binds to and dephosphorylates'Ser-15' of TP53 and'Ser-345' of CHEK1 which leads to the functional inactivation of these proteins (PubMed:15870257, PubMed:16311512). Mediates MAPK14 dephosphorylation and inactivation (PubMed:21283629).

Gene Information

Human
Gene Name:	PPM1D
Uniprot:	O15297
Entrez:	8493

Family

Belongs to:

PP2C family

Alternative Names

EC 3.1.3.16; p53-induced protein phosphatase 1; PP2C-delta; PPM1D; protein phosphatase 1D magnesium-dependent, delta isoform; protein phosphatase 1D; protein phosphatase 2C delta isoform; Protein phosphatase 2C isoform delta; Protein phosphatase magnesium-dependent 1 delta; protein phosphatase, Mg2+/Mn2+ dependent, 1D; wild-type p53-induced phosphatase 1; Wip1; WIP1protein phosphatase Wip1

Molecular Weight

Mass (kDA):
66.675 kDA

Genomic Context


Human

Location:	17q23.2
Sequence:	17; NC_000017.11 (60600187..60666280)

Tissue Specificity

Expressed in fetal and adult brain. Also detected in fetal liver and skeletal muscle, but not in their adult counterparts.

Subcellular Localizations

Nucleus. Cytoplasm, cytosol.

Diseases

Malignant Neoplasms
Neoplasms
Mammary Neoplasms
Malignant Neoplasm Of Breast
Cell Transformation, Neoplastic
Carcinoma
Malignant Paraganglionic Neoplasm
Ataxia Telangiectasia
Adenocarcinoma
Genotoxic Stress
Ductal Breast Carcinoma
Ataxia

Medulloblastoma
Ovarian Neoplasm
Genomic Instability
Osteosarcoma
Malignant Neoplasm Of Ovary
Telangiectasis
Malignant Neoplasm Of Brain

Interacting Proteins

H2AFX
MDM2
RUNX2

Pathways

Cell Cycle
Dna Repair
Cell Death
Rna Interference
Cell Cycle Checkpoint
Cell Cycle Arrest
Cell Proliferation
Localization
Cell Growth
Mrna Stabilization
Dna Damage Checkpoint
Pathogenesis
Gene Silencing

Aging
Translation
Response To Uv
Regulation Of Cell Cycle
Senescence
Protein Phosphorylation
Programmed Cell Death

PTMs

Phosphorylation
Dephosphorylation

Ubiquitination
Cleavage

Methylation

Research Areas

Cell Cycle and Replication

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PPM1D

References

PMID: 9177166 by Fiscella M., et al. Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner.

PMID: 15870257 by Lu X., et al. PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints.