Protein phosphatase 1D Antibodies

Protein phosphatase 1D (PPM1D)

Involved in the negative regulation of p53 expression (PubMed:23242139). Required for the aid of p53-dependent checkpoint mediated cell cycle arrest.

Binds to and dephosphorylates'Ser-15' of TP53 and'Ser-345' of CHEK1 which leads to the functional inactivation of these proteins (PubMed:15870257, PubMed:16311512). Mediates MAPK14 dephosphorylation and inactivation (PubMed:21283629).

Gene Information

Human
Gene Name:	PPM1D
Uniprot:	O15297
Entrez:	8493

Family

Belongs to:
PP2C family

Alternative Names

EC 3.1.3.16; p53-induced protein phosphatase 1; PP2C-delta; PPM1D; protein phosphatase 1D magnesium-dependent, delta isoform; protein phosphatase 1D; protein phosphatase 2C delta isoform; Protein phosphatase 2C isoform delta; Protein phosphatase magnesium-dependent 1 delta; protein phosphatase, Mg2+/Mn2+ dependent, 1D; wild-type p53-induced phosphatase 1; Wip1; WIP1protein phosphatase Wip1

Molecular Weight

Mass (kDA):
66.675 kDA

Genomic Context

Human
Location:	17q23.2
Sequence:	17; NC_000017.11 (60600187..60666280)

Tissue Specificity

Expressed in fetal and adult brain. Also detected in fetal liver and skeletal muscle, but not in their adult counterparts.

Subcellular Localizations

Nucleus. Cytoplasm, cytosol.

Diseases

• Malignant Neoplasms
• Neoplasms
• Mammary Neoplasms
• Malignant Neoplasm Of Breast
• Cell Transformation, Neoplastic
• Carcinoma
• Malignant Paraganglionic Neoplasm
• Ataxia Telangiectasia
• Adenocarcinoma
• Genotoxic Stress
• Ductal Breast Carcinoma
• Ataxia

• Medulloblastoma
• Ovarian Neoplasm
• Genomic Instability
• Osteosarcoma
• Malignant Neoplasm Of Ovary
• Telangiectasis
• Malignant Neoplasm Of Brain

Interacting Proteins

• H2AFX
• MDM2
• RUNX2

Pathways

• Cell Cycle
• Dna Repair
• Cell Death
• Rna Interference
• Cell Cycle Checkpoint
• Cell Cycle Arrest
• Cell Proliferation
• Localization
• Cell Growth
• Mrna Stabilization
• Dna Damage Checkpoint
• Pathogenesis
• Gene Silencing

• Aging
• Translation
• Response To Uv
• Regulation Of Cell Cycle
• Senescence
• Protein Phosphorylation
• Programmed Cell Death

PTMs

• Phosphorylation
• Dephosphorylation

• Ubiquitination
• Cleavage

• Methylation

Research Areas

• Cell Cycle and Replication

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PPM1D

Boster Bio Anti-PPM1D/WIP1 Picoband(tm) Antibody

This article will cover the Boster Bio Anti-PPM1D/WIP1 picoband(tm), Antibody, and the benefits of using it. We'll also review the other Boster antibodies. Interested? Keep reading! Keep reading!

Boster Bio Anti-PPM1D/WIP1 Picoband(tm) Antibody

The Boster Bio Anti–PPM1D (PPM1D/WIP1) Picoband(tm), Antibody recognizes Human. It is stored at -20degC for one year and at 4degC for a month. Each vial contains 4 mg of Trehalose and 0.2mg of Na2HPO4. The product is compatible with a range of biochemical systems.

The PPM1D Marker has many benefits

A variety of studies have been conducted and revealed that patients suffering from diverse types of tumors expressed higher levels of PPM1D mRNA. PPM1D expression is more prevalent in certain types of cancers like HCC, lung carcinoma and renal chromophobe. Apart from lung tumors, PPM1D was also detected in esophageal cancer and the glioblastoma multiforme. PRAD has been shown to be more prevalent in certain types of tumors, like testicular germ cells tumors.

Researchers have found that mutations in PPM1D hinders the recovery of cells from G2 checkpoint. The mutation hinders recovery after checkpoint arrest and is associated with various cancers. The PPM1D gene acts as a negative regulator for p53. PPM1D mutations can cause gain-of-function and truncating mutations in the gene.

The gene that encodes PPM1D is expressed on monocytes, TAMs and DCs. It also correlates with Th2 and Th2 markers cells, like IRF5 and BDCA-4. It has been also shown that the PPM1D marker is associated with TNF, GATA3, STAT6 and is highly correlated with FOXP3 expression and IL-17A.

The PPM1D Marker can be used to detect the presence of the protein in human tumors. The PPM1D gene expression is linked to different aspects of progression of cancer such as the number of immune cells. In addition, high levels of PPM1D is associated with lower PFS and OS in HCC while low expression correlates with long life expectancy. These results suggest that PPM1D might be a prognostic biomarker.

Other antibodies available from Boster

Wuhan Boster Biological Technology, Ltd. was established in 1993. It is a specialist in antibodies and immunological reagents. The company has more than 12,000 antibodies available in its portfolio, including picogram sensitivity ELISA kits as well as IHC/WB compatible antibodies. These antibodies have been confirmed by binding to known quantities of recombinant proteins as well as cell lines. Moreover, the company offers its products in various formats which include ELISA kits and immunological Reagents.

These antibodies are distinguished by high affinity, which makes them an ideal choice for research projects. Boster provides high-affinity antibody with extensive validation that have been widely cited over the last 25 years. In addition, its antibodies are used extensively for immunohistochemistry, Western Blotting, and ELISA applications. The company's products are used worldwide by researchers and is a major provider of catalog antibodies.