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- Table of Contents
Facts about Protein phosphatase 1A.
Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.
Human | |
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Gene Name: | PPM1A |
Uniprot: | P35813 |
Entrez: | 5494 |
Belongs to: |
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PP2C family |
EC 3.1.3.16; FLJ42306; MGC9201; MMPa-2; MPPa-1; phosphatase 2C alpha; PP2C alpha; Pp2c1; PP2CA; PP2Calpha; PP2C-ALPHA; PPM1A; PPPM1A; protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform; protein phosphatase 1A; protein phosphatase 2C alpha isoform; Protein phosphatase 2C isoform alpha; Protein phosphatase IA; protein phosphatase, Mg2+/Mn2+ dependent, 1A
Mass (kDA):
42.448 kDA
Human | |
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Location: | 14q23.1 |
Sequence: | 14; NC_000014.9 (60245750..60299087) |
Nucleus. Cytoplasm, cytosol. Membrane; Lipid-anchor. Weakly associates at the membrane and N-myristoylation mediates the membrane localization.
PMID: 1311954 by Mann D.J., et al. Mammalian protein serine/threonine phosphatase 2C: cDNA cloning and comparative analysis of amino acid sequences.
PMID: 9707433 by Takekawa M., et al. Protein phosphatase 2Calpha inhibits the human stress-responsive p38 and JNK MAPK pathways.