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PPIF Antibodies
AND PPIF ELISA kits, PPIF Proteins
Many biological assays use antibodies to detect PPIF, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PPIF in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PPIF antibodies...
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PPIF Infographic by Boster Bio
All PPIF Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IP, IHC, WB
$370
Cat # M02803
100 μl
Cat # M02803
100 μl
Human, Mouse, Rat
ELISA
$480
Cat # EKC1705
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1705
1 kit, containing one 96-well plate and all necessary reagents
SDS-PAGE
$250
Cat # PROTP29117
Starting from 20ug
Cat # PROTP29117
Starting from 20ug
Enzyme Activity, SDS-PAGE
$234
Cat # PROTP30405
Starting from 20ug
Cat # PROTP30405
Starting from 20ug
Human, Mouse, Rat
IHC, WB
$523
Cat # M02803-1
100 µl
Cat # M02803-1
100 µl
PPIF Overview
Facts about Peptidyl-prolyl cis-trans isomerase F, mitochondrial.
Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIF)
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Involved in regulation of the mitochondrial permeability transition pore (mPTP).
It is suggested that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this particular purpose is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis.
Gene Information
| Human | |
|---|---|
| Gene Name: | PPIF |
| Uniprot: | P30405 |
| Entrez: | 10105 |
Family
| Belongs to: |
|---|
| cyclophilin-type PPIase family |
Alternative Names
Cyclophilin F; CYP3FLJ90798; Cyp-D; hCyP3; MGC117207; mitochondrial; peptidyl-prolyl cis-trans isomerase, mitochondrial; peptidylprolyl isomerase F (cyclophilin F); peptidylprolyl isomerase F
Molecular Weight
Mass (kDA):
22.04 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q22.3 |
| Sequence: | 10; NC_000010.11 (79347469..79355334) |
Subcellular Localizations
Mitochondrion matrix.
Diseases
- Edema
- Cardiomyopathies
- Cardiomyopathy, Dilated
- Heart Failure
- Cardiomyopathy, Familial Idiopathic
- Abnormal Behavior
- Right Ventricular Hypertrophy
- Malnutrition
- Drug-induced Liver Injury
- Cardiac Hypertrophy
- Hypoxia
- Muscular Dystrophy, Duchenne
- Mitochondrial Damage
Interacting Proteins
- ABI2
- BANP
- CMTM5
- TP53
Pathways
- Cell Death
- Necrotic Cell Death
- Pathogenesis
- Methylation
- Programmed Cell Death
- Circadian Rhythm
- Prolactin Secretion
- Mitochondrial Depolarization
PTMs
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PPIF
bosterbio.com/bosterbio-gene-info-cards/PPIF
References
PMID: 1744118 by Bergsma D.J., et al. The cyclophilin multigene family of peptidyl-prolyl isomerases. Characterization of three separate human isoforms.
PMID: 10406942 by Johnson N., et al. Import and processing of heart mitochondrial cyclophilin D.