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- Table of Contents
Facts about Peptidyl-prolyl cis-trans isomerase E.
Binds mRNA and has a preference for single-stranded RNA molecules with poly-A and poly-U stretches, suggesting it binds to the poly(A)-region in the 3'-UTR of mRNA molecules (PubMed:8977107, PubMed:18258190, PubMed:20460131). Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins (PubMed:8977107, PubMed:18258190, PubMed:20677832, PubMed:20541251).
Human | |
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Gene Name: | PPIE |
Uniprot: | Q9UNP9 |
Entrez: | 10450 |
Belongs to: |
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cyclophilin-type PPIase family |
Cyclophilin E; cyclophilin-33; CYP33; CyP-33; EC 5.2.1.8; MGC111222; MGC3736; peptidyl-prolyl cis-trans isomerase E; peptidylprolyl isomerase E (cyclophilin E); PPIase E; Rotamase E
Mass (kDA):
33.431 kDA
Human | |
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Location: | 1p34.2 |
Sequence: | 1; NC_000001.11 (39738845..39765698) |
Found in all the examined tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Nucleus.
PMID: 9747881 by Kim J.-O., et al. Co-amplification of a novel cyclophilin-like gene (PPIE) with L-myc in small cell lung cancer cell lines.
PMID: 8977107 by Mi H., et al. A nuclear RNA-binding cyclophilin in human T cells.