PPIA Antibodies

Peptidyl-prolyl cis-trans isomerase A (PPIA)

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

.

Gene Information

Human
Gene Name:	PPIA
Uniprot:	P62937
Entrez:	5478

Family

Belongs to:
cyclophilin-type PPIase family

Alternative Names

Cyclophilin A; Cyclosporin A-binding protein; CYPA; CYPAMGC12404; CYPH; EC 5.2.1.8; MGC117158; MGC23397; peptidyl-prolyl cis-trans isomerase A; peptidylprolyl isomerase A (cyclophilin A); PPIA; PPIase A; Rotamase A; Rotamase; T cell cyclophilin

Molecular Weight

Mass (kDA):
18.012 kDA

Genomic Context

Human
Location:	7p13
Sequence:	7; NC_000007.14 (44795960..44803117)

Subcellular Localizations

Cytoplasm. Secreted. Secretion occurs in response to oxidative stress in vascular smooth muscle through a vesicular secretory pathway that involves actin remodeling and myosin II activation, and mediates ERK1/2 activation.

Diseases

• Malignant Neoplasms
• Neoplasms
• Carcinoma
• Anxiety Disorders
• Malignant Paraganglionic Neoplasm
• Malignant Neoplasm Of Prostate
• Malignant Neoplasm Of Breast
• Mammary Neoplasms
• Inflammation
• Hiv Infections
• Hypoxia
• Prostatic Neoplasms
• Renal Cell Carcinoma

• Cell Transformation, Neoplastic
• Kidney Neoplasm
• Immunologic Deficiency Syndromes
• Ovarian Neoplasm
• Infarction
• Malignant Neoplasm Of Lung
• Myocardial Infarction

Interacting Proteins

• LNX1
• PTPRN
• SUPT5H

Pathways

• Reverse Transcription
• Protein Folding
• Pathogenesis
• Cell Proliferation
• Ovulation
• Transport
• Cell Cycle
• Cell Death
• Cell Adhesion
• Dna Methylation
• Regeneration
• Virulence
• Inflammatory Response

• Liver Regeneration
• Methylation
• Drug Resistance
• Cytokine Production
• Viral Replication
• Secretion
• Cell Activation

PTMs

• Phosphorylation
• Oxidation

• Reduction
• Glycosylation

• Methylation

Research Areas

• Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PPIA

Best Uses Of The PPIA Marker

When you're setting up your Boster Bio experiment, you'll be confronted with a lot of questions. There are a variety of optimization guidebooks and troubleshooting tutorials available and they can help you eliminate numerous potential sources of error. Boster Bio guides are a great method for you to master the techniques and make your research more productive. The guide will assist you in identifying possible causes of error and make necessary adjustments.

Boster Bio optimization guides assist to eliminate a number of errors that could be caused by a variety of sources

There are several methods to optimize your experiments. Boster Bio optimization guides will help you eliminate the possibilities of error and provide step-by-step instructions for the most commonly used flow cytometry steps. Utilizing the right buffers and controls, you can remove a range of errors that could be caused by. If there are too many variables involved, flow cytometry tests could become extremely complex.

Immunohistochemistry is based on the idea that antibodies attach to antigens to detect antigens in cells. Immunohistochemistry optimization is a critical element of the process. The Boster Bio guide will provide in-depth details on antigen retrieval, embedding, fixation and fixation as well as other important IHC sample preparation steps. You will also learn how to optimally stain different types of preserved tissue.

Boster Bio troubleshooting manuals help eliminate a variety of possible causes of error

A Boster Bio troubleshooting guide will help you figure out what is causing a saturation signal, and what you can do to solve the issue. If you've tried the Boster Bio kit and have experienced a saturation signal check out the Boster Bio troubleshooting guide to eliminate the most likely reasons for saturation signals. Troubleshooting guides can also help you determine the proper guidelines to follow in your experiment to reduce the risk of contamination.

The guide includes detailed step-bystep procedures, illustrations of workflow and recommended the reagents. A comprehensive guide is vital for IHC. The best staining technique begins with proper tissue preparation. Many guides provide information on the retrieval of antigen, fixation embedding, as well as preparation of samples. Different types of tissue preserved require different procedures. This is why the preparation is so important.