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- Table of Contents
20 Citations 16 Q&As
3 Citations
Facts about Peroxisome proliferator-activated receptor gamma.
It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis.
Human | |
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Gene Name: | PPARG |
Uniprot: | P37231 |
Entrez: | 5468 |
Belongs to: |
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nuclear hormone receptor family |
CIMT1; NR1C3; NR1C3GLM1; Nuclear receptor subfamily 1 group C member 3; peroxisome proliferator-activated receptor gamma 1; peroxisome proliferator-activated receptor gamma; PPAR gamma; PPARG; PPARG1peroxisome proliferative activated receptor, gamma; PPARG2PPARgamma; PPAR-gamma
Mass (kDA):
57.62 kDA
Human | |
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Location: | 3p25.2 |
Sequence: | 3; NC_000003.12 (12287485..12434344) |
Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary.
Nucleus. Cytoplasm. Redistributed from the nucleus to the cytosol through a MAP2K1/MEK1-dependent manner. NOCT enhances its nuclear translocation.
PMID: 9065481 by Mukherjee R., et al. Identification, characterization, and tissue distribution of human peroxisome proliferator-activated receptor (PPAR) isoforms PPARgamma2 versus PPARgamma1 and activation with retinoid X receptor agonists and antagonists.
PMID: 8702406 by Elbrecht A., et al. Molecular cloning, expression and characterization of human peroxisome proliferator activated receptors gamma 1 and gamma 2.
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