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MED1 Antibodies
AND MED1 ELISA kits, MED1 Proteins
Many biological assays use antibodies to detect MED1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MED1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MED1 antibodies...
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MED1 Infographic by Boster Bio
All MED1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA
$480
Cat # EKC1826
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1826
1 kit, containing one 96-well plate and all necessary reagents
Human, Monkey, Mouse
ELISA, IF, IHC, WB
$380
Cat # A00550T1457
100ul
Cat # A00550T1457
100ul
MED1 Overview
Facts about Mediator of RNA polymerase II transcription subunit 1.
Mediator of RNA polymerase II transcription subunit 1 (MED1)
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator acts as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
Mediator is recruited to promoters by direct interactions with regulatory proteins and functions as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).
Gene Information
| Human | |
|---|---|
| Gene Name: | MED1 |
| Uniprot: | Q15648 |
| Entrez: | 5469 |
Family
| Belongs to: |
|---|
| Mediator complex subunit 1 family |
Alternative Names
Activator-recruited cofactor 205 kDa component; ARC205; CRSP1TRIP2; CRSP200p53 regulatory protein RB18A; DRIP230; DRIP230PPAR-binding protein; MBD4; MED1; mediator complex subunit 1DRIP205; mediator of RNA polymerase II transcription subunit 1; PBPPPARGBP; Peroxisome proliferator-activated receptor-binding protein; PPAR binding protein; PPARBP; PPARBPMGC71488; PPARG binding protein; PPARGBP; RB18ATR-interacting protein 2; Thyroid hormone receptor-associated protein complex 220 kDa component; thyroid hormone receptor-associated protein complex component TRAP220; thyroid receptor interacting pro
Molecular Weight
Mass (kDA):
168.478 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q12 |
| Sequence: | 17; NC_000017.11 (39404285..39451281, complement) |
Tissue Specificity
Ubiquitously expressed.
Subcellular Localizations
Nucleus. A subset of the protein may enter the nucleolus subsequent to phosphorylation by MAPK1 or MAPK3.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Carcinoma
- Microsatellite Instability
- Lung Neoplasms
- Prostatic Neoplasms
- Malignant Neoplasm Of Prostate
- Mutation, Out-of-frame
- Liver Carcinoma
- Inflammatory Response
- Cell Invasion
Interacting Proteins
- ESR1
- GATA1
- MED21
- MED7
- RARA
- RXRA
- THRA
- VDR
Pathways
- Mismatch Repair
- Dna Repair
- Methylation
- Cell Cycle
- Cell Proliferation
- Histone Acetylation
- Chromatin Remodeling
- Pathogenesis
- Cell Growth
- Mammary Gland Development
- Gland Development
- Keratinocyte Differentiation
- Inflammatory Response
PTMs
- Phosphorylation
- Acetylation
- Methylation
- Deamination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MED1
bosterbio.com/bosterbio-gene-info-cards/MED1
References
PMID: 9444950 by Drane P., et al. Identification of RB18A, a 205 kDa new p53 regulatory protein which shares antigenic and functional properties with p53.
PMID: 9653119 by Yuan C.-X., et al. The TRAP220 component of a thyroid hormone receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion.