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POU4F2 Antibodies
AND POU4F2 ELISA kits, POU4F2 Proteins
Many biological assays use antibodies to detect POU4F2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with POU4F2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop POU4F2 antibodies...
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POU4F2 Overview
Facts about POU domain, class 4, transcription factor 2.
POU domain, class 4, transcription factor 2 (POU4F2)
Functions either as activator or repressor regulating the rate of target gene transcription through RNA polymerase II receptor at a promoter-dependent manner (PubMed:19266028, PubMed:23805044). Binds to the consensus octamer motif 5'-AT[A/T]A[T/A]T[A/T]A-3' of promoter of target genes.
Plays a fundamental role in the gene regulatory system necessary for retinal ganglion cell (RGC) differentiation. Binds to an octamer site to form a ternary complex with ISL1; cooperates favorably with ISL1 and ISL2 to potentiate transcriptional activation of RGC target genes being included in RGC fate commitment in the developing retina and RGC axon formation and pathfinding.
Gene Information
| Human | |
|---|---|
| Gene Name: | POU4F2 |
| Uniprot: | Q12837 |
| Entrez: | 5458 |
Family
| Belongs to: |
|---|
| POU transcription factor family |
Alternative Names
POU domain, class 4, transcription factor 2; BRN3.2; BRN3B; Brn-3b; POU class 4 homeobox 2
Molecular Weight
Mass (kDA):
43.087 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4q31.22 |
| Sequence: | 4; NC_000004.12 (146638893..146642474) |
Tissue Specificity
Expressed in the brain (PubMed:7691107). Expressed in the ganglion cell layer of the retina (PubMed:7691107).
Subcellular Localizations
Nucleus. Nucleus speckle. Cytoplasm.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Neuroblastoma
- Nervousness
- Cell Invasion
- Cell Transformation, Neoplastic
- Nerve Degeneration
- Disorder Of The Optic Nerve
- Microphthalmos
- Neoplasm Invasiveness
- Malignant Neoplasm Of Urinary Bladder
Interacting Proteins
- GRN
- KPRP
- KRTAP10-9
- KRTAP12-1
- KRTAP12-3
- KRTAP4-12
- KRTAP9-2
- KRTAP9-8
Pathways
- Cell Cycle
- Neurogenesis
- Cell Development
- Cell Differentiation
- Cell Growth
- Methylation
- Regulation Of Gene Expression
- System Development
- Cell Proliferation
- Localization
- Drug Resistance
- Cell Death
- Cell Migration
PTMs
- Methylation
Research Areas
- Neuroscience
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/POU4F2
bosterbio.com/bosterbio-gene-info-cards/POU4F2
References
PMID: 7691107 by Xiang M., et al. Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells.
PMID: 8332509 by Ring C.J.A., et al. The human Brn-3b POU transcription factor shows only limited homology to the Brn-3a/RDC-1 factor outside the conserved POU domain.