POU4F3 Antibodies

AND POU4F3 ELISA kits, POU4F3 Proteins

Many biological assays use antibodies to detect POU4F3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with POU4F3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop POU4F3 antibodies...

We validate the specificity of these antibodies to POU4F3 by testing them on tissues known to express POU4F3 positively and negatively. Browse below to find the POU4F3 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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POU4F3 Infographic by Boster Bio

All POU4F3 Products

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Product

Figures

Specificity

Applications

Price

Anti-Brn-3c POU4F3 Antibody

Human, Mouse, Rat

$405
Cat # A06338
100ul

Anti-POU4F3 Mouse Monoclonal Antibody [Clone ID: OTI4C5]

Human, Mouse, Rat

$523
Cat # M06338
100 µl

POU4F3 (NM_002700) Human Over-expression Lysate

Human

$628
Cat # LS005459
100 µg

POU4F3 Overview

Facts about POU domain, class 4, transcription factor 3.

POU4F3 3D structure. Source: alphafold

POU domain, class 4, transcription factor 3 (POU4F3)

Acts as a transcriptional activator (PubMed:18228599). Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes (PubMed:18228599).

Involved in the auditory system development, necessary for terminal differentiation of hair cells in the inner ear (By similarity). .

Gene Information

Human
Gene Name:	POU4F3
Uniprot:	Q15319
Entrez:	5459

Family

Belongs to:

POU transcription factor family

Alternative Names

brain-3C; Brain-specific homeobox/POU domain protein 3C; BRN3.1; Brn-3C; BRN3Cbrn-3C; DFNA15; MGC138412; POU class 4 homeobox 3; POU domain class 4, transcription factor 3; POU domain, class 4, transcription factor 3

Molecular Weight

Mass (kDA):
37.052 kDA

Genomic Context


Human

Location:	5q32
Sequence:	5; NC_000005.10 (146338839..146341728)

Tissue Specificity

Brain. Seems to be specific to the retina.

Subcellular Localizations

Nucleus. Cytoplasm. Preferentially localized in the nucleus.

Diseases

Complete Hearing Loss
Sensorineural Hearing Loss (disorder)
Deafness Congenital
Hearing Problem
Cytopathic Effect
Wolfram Syndrome
Malnutrition
Macule
Posterior Reversible Encephalopathy Syndrome
Conductive Hearing Loss
Diphtheria
Eye Abnormalities

Leukemia, Myelocytic, Acute
Nerve Transections, Optic
Myeloid Leukemia
Neoplasms
Nervousness
Presbycusis
Cytogenetic Abnormality

Pathways

Cell Differentiation
Hair Cell Differentiation
Cell Development
Localization
Regeneration
Cell Death
Innervation
Pathogenesis
Transdifferentiation
Transport
Brain Development
Aging
Sensory System Development

Neurogenesis
Inner Ear Development
Methylation
Drug Resistance
Notch Signaling Pathway
System Development
Ear Development

PTMs

Methylation

Research Areas

Neuroscience
Vision

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/POU4F3

References

PMID: 7623109 by Xiang M., et al. The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons.

PMID: 9506947 by Vahava O., et al. Mutation in transcription factor POU4F3 associated with inherited progressive hearing loss in humans.