POLR3A Antibodies

AND POLR3A ELISA kits, POLR3A Proteins

Many biological assays use antibodies to detect POLR3A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with POLR3A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop POLR3A antibodies...

We validate the specificity of these antibodies to POLR3A by testing them on tissues known to express POLR3A positively and negatively. Browse below to find the POLR3A antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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POLR3A Infographic by Boster Bio

All POLR3A Products

Product

Figures

Specificity

Applications

Price

Anti-POLR3A Antibody

7 Q&As

Human, Monkey, Mouse

$399
Cat # A06059
100μl

Anti-RPC1 POLR3A Antibody

1 Q&As

Human, Monkey, Mouse

ELISA, IHC-P, WB, IF (paraffin)

$335
Cat # A30651
100ul

Anti-POLR3A (P68) Antibody

Human, Mouse, Rat

IHC, WB

$405
Cat # A06059-1
100ul

POLR3A Overview

Facts about DNA-directed RNA polymerase III subunit RPC1.

POLR3A 3D structure. Source: alphafold

DNA-directed RNA polymerase III subunit RPC1 (POLR3A)

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.

Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III.

Gene Information

Human
Gene Name:	POLR3A
Uniprot:	O14802
Entrez:	11128

Family

Belongs to:

RNA polymerase beta' chain family

Alternative Names

DNA-directed RNA polymerase III largest subunit; DNA-directed RNA polymerase III subunit A; DNA-directed RNA polymerase III subunit RPC1; EC 2.7.7.6; hRPC155; POL3A; polymerase (RNA) III (DNA directed) polypeptide A, 155kDa; RNA polymerase III 155 kDa subunit; RNA polymerase III subunit C160; RNA polymerase III subunit RPC155-D; RPC1; RPC155RNA polymerase III subunit C1

Molecular Weight

Mass (kDA):
155.641 kDA

Genomic Context


Human

Location:	10q22.3
Sequence:	10; NC_000010.11 (77975149..78029515, complement)

Tissue Specificity

Expressed in the brain, in the cortex and the white matter (at protein level).

Subcellular Localizations

Nucleus.

Diseases

Hypogonadotropic Hypogonadism
Hypodontia
Hypogonadism
Leukodystrophy
Ataxia
Leukoencephalopathies
Atrophy
Somatotropin Deficiency
Cerebellar Diseases
Neurodegenerative Disorders

Exanthema
Pituitary Dwarfism
Nervousness
Developmental Absence Of Tooth

Pathways

Tooth Eruption

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/POLR3A

References

PMID: 9331371 by Sepehri S., et al. The largest subunit of human RNA polymerase III is closely related to the largest subunit of yeast and trypanosome RNA polymerase III.

PMID: 12384934 by Kuwana M., et al. Identification of an immunodominant epitope on RNA polymerase III recognized by systemic sclerosis sera: application to enzyme-linked immunosorbent assay.