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- Table of Contents
1 Q&As
Facts about DNA-directed RNA polymerase III subunit RPC1.
Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III.
Human | |
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Gene Name: | POLR3A |
Uniprot: | O14802 |
Entrez: | 11128 |
Belongs to: |
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RNA polymerase beta' chain family |
DNA-directed RNA polymerase III largest subunit; DNA-directed RNA polymerase III subunit A; DNA-directed RNA polymerase III subunit RPC1; EC 2.7.7.6; hRPC155; POL3A; polymerase (RNA) III (DNA directed) polypeptide A, 155kDa; RNA polymerase III 155 kDa subunit; RNA polymerase III subunit C160; RNA polymerase III subunit RPC155-D; RPC1; RPC155RNA polymerase III subunit C1
Mass (kDA):
155.641 kDA
Human | |
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Location: | 10q22.3 |
Sequence: | 10; NC_000010.11 (77975149..78029515, complement) |
Expressed in the brain, in the cortex and the white matter (at protein level).
Nucleus.
PMID: 9331371 by Sepehri S., et al. The largest subunit of human RNA polymerase III is closely related to the largest subunit of yeast and trypanosome RNA polymerase III.
PMID: 12384934 by Kuwana M., et al. Identification of an immunodominant epitope on RNA polymerase III recognized by systemic sclerosis sera: application to enzyme-linked immunosorbent assay.