POLD1 Antibodies

AND POLD1 ELISA kits, POLD1 Proteins

Many biological assays use antibodies to detect POLD1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with POLD1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop POLD1 antibodies...

We validate the specificity of these antibodies to POLD1 by testing them on tissues known to express POLD1 positively and negatively. Browse below to find the POLD1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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POLD1 Infographic by Boster Bio

All POLD1 Products

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Product

Figures

Specificity

Applications

Price

Anti-POLD1 Antibody

1 Q&As

Human, Mouse, Rat

ELISA, WB

$335
Cat # A30643
100ul

Anti-DNA pol Delta cat POLD1 Antibody

Human, Mouse, Rat

IF, IHC, WB

$405
Cat # A03720-1
100ul

Anti-POLD1 Rabbit Monoclonal Antibody

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # M03720
100 μl/vial

POLD1 (NM_002691) Human Over-expression Lysate

Human

$628
Cat # LS005424
100 µg

POLD1 Overview

Facts about DNA polymerase delta catalytic subunit.

POLD1 3D structure. Source: alphafold

DNA polymerase delta catalytic subunit (POLD1)

As the catalytic part of the trimeric (Pol-delta3 complicated ) and tetrameric DNA polymerase delta complexes (Pol-delta4 complicated ), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and fix. Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity.

Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol-delta4), displays differences in catalytic activity. Most notably, expresses higher proofreading activity in the context of Pol-delta3 compared with that of Pol-delta4 (PubMed:19074196, PubMed:20334433).

Gene Information

Human
Gene Name:	POLD1
Uniprot:	P28340
Entrez:	5424

Family

Belongs to:

DNA polymerase type-B family

Alternative Names

CDC2 homolog; CDC2; DNA polymerase delta catalytic subunit; DNA polymerase subunit delta p125; DNA-directed polymerase delta 1; EC 2.7.7.7; POLD; polymerase (DNA directed), delta 1, catalytic subunit (125kD); polymerase (DNA directed), delta 1, catalytic subunit 125kDa

Molecular Weight

Mass (kDA):
123.631 kDA

Genomic Context


Human

Location:	19q13.33
Sequence:	19; NC_000019.10 (50384291..50418018)

Tissue Specificity

Widely expressed, with high levels of expression in heart and lung.

Subcellular Localizations

Nucleus. Colocalizes with PCNA and POLD3 at S phase replication sites (PubMed:11595739). After UV irradiation, recruited to DNA damage sites within 2 hours, independently on the cell cycle phase, nor on PCNA ubiquitination. This recruitment requires POLD3, PCNA and RFC1-replication factor C complex (PubMed:20227374, PubMed:22801543).